International Journal of Scientific & Technology Research

IJSTR@Facebook IJSTR@Twitter IJSTR@Linkedin
Home About Us Scope Editorial Board Blog/Latest News Contact Us

IJSTR >> Volume 6 - Issue 1, January 2017 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616

Nanopore Sequencing: A Survey

[Full Text]



Muhammad Zunnurain Hussain, Muhammad Zulkifl Hasan



DNA Sequencing, Nanopore, Nanoelectrodes, Single molecule measurement, Solid-State Nanopore.



A single molecule of Deoxyribonucleic acid (DNA) is being sequenced by using an innovative concept of Nanopore. The orientation of nanopore define the channel of ions through the pore comes into contact with nucleotide, the permutation and the transition kinematics of each molecule of DNA. The divergence of electrical signal observed when the four chemical bases adenine (A), guanine (G), cytosine (C), and thymine (T), present in the DNA passed through the nanopore is being determined. This led to next generation bioengineering and reduces the cost and time of mammalian genome sequencing and makes the process of DNA sequencing extremely easy and easily accessible.



[1] D. &. D. W. D. e. a. Branton, "The Potential and Challenges of Nanopore Sequencing," Nature Biotechnology 26, pp. 1146 - 1153, 2008.

[2] e. a. Yoshimitsu Yanagawa, "Fluctuation tolerant read scheme for ultrafast DNA sequencing with nanopore device," IEEE International Symposium on Circuits and Systems (ISCAS), 2012, 2012.

[3] R. S. A. G. R. A. S. L. Z. H. M. L. Y. He1, "DNA Sequencing with nanopore-embedded bilayer-graphene nanoelectrodes," Solid-State and Integrated Circuit Technology (ICSICT), 2010, 2010.

[4] A. T. K. a. J. A. Golovchenko, "Nanometer-thin solid-state nanopores by cold ion beam sculpting," American Institute of Physics., 2012.

[5] P. Patel, "Advance in Nanopore Gene Sequencing," Spectrum, IEEE, vol. 46, p. 14, 2009.

[6] S. T. a. A. K. Eric E. Schadt, "A window into third-generation sequencing," Human Molecular Genetics, pp. 227 - 240, 2010.

[7] T. Z. B. M. D. C. E. M. M. P. M. N. a. J. H. G. Ian M. Derringtona, "Nanopore DNA sequencing with MspA," Proceedings of the National Academy of Sciences, pp. 16060-16065, 2010.

[8] I. M. D. M. P. M. N. J. H. G. Elizabeth A. Manrao, "Nucleotide Discrimination with DNA Immobilized in the MspA Nanopore," PloS One, pp. 1 - 8, 2011.

[9] M. N. T. T. S. K. Akira Mizuno, "Handling of a single DNA molecule using electric field and laser beam," IEEE transcation, pp. 1452-1457, 1995.

[10] B. A. P. John A. Lund, "Molding single DNA molecules in metals and sample preparation for electronic sequencing," IEEE 31st Annual International Conference of the IEEE EMBS Minneapolis, Minnesota, USA,, pp. 2779-2782, September 2-6, 2009.

[11] K. S. Sebastian Sorgenfrei, "single-molecule electronic detection using nanoscale field-effect devices," ACM / EDAC,2011 IEEE, pp. 712 - 717, 2011.

[12] I. I. T. I. K. ITakahito Ohshiro, "Tunnel-current based single-molecule identification of DNA/RNA oligmer by using nano-MCBJ," 2012 12th IEEE International Conference on Nanotechnology (IEEE- NANO), pp. 1 - 2, 2011.

[13] Z. L. J. O. Yau Wong, "Effect of Time Discretization on the Limit of the Accuracy of Parameter Estimation for Moving Single Molecules Imaged by Fluorescence Microscopy," 9th IEEE International , pp. 1228-1231, 2012.

[14] R. S. A. G. R. A. S. L. Z. H. M. L. Y. He1, "DNA Sequencing with nanopore-embedded bilayer-graphene nanoelectrodes," Solid-State and Integrated Circuit Technology (ICSICT), 2010, pp. 1483 - 1485 , 2010.

[15] J. Shim, V. Solovyeva, D. Estrada, S. Banerjee, J. Rivera, E. Pop and R. Bashir, "Graphene Nanopores for Nucleic Acid Analysis," Nanotechnology (IEEE-NANO), 2012 12th IEEE Conference , pp. 1 - 2, 2012.

[16] G. V. S. a. A. Meller, "Progress toward Ultrafast DNA Sequencing Using Solid-State Nanopores," The American Association for Clinical Chemistry, vol. 53, no. 11, pp. 1996 - 2001, 2007.

[17] A. M. James Weifu Lee1, "Rapid DNA Sequencing by Direct Nanoscale Reading of Nucleotide Bases on Individual DNA chains," New High Throughput Technologies for DNA Sequencing and Genomics, vol. 2, p. 245263, 2007.

[18] B. Pathak, H. Lofas, J. Prasongkit, A. Grigoriev, R. Ahuja and R. H. Scheicher, " Double-functionalized nanopore-embedded gold electrodes for rapid DNA sequencing," Applied Physics Letters , vol. 100, no. 2, pp. 023701 - 023701-3 , 2012.

[19] S. H. . J. H. . F. L. . P. Z. . S. L. . X. C. . O. S. . a. S. L. *. Shuai Chang , "Electronic Signatures of all Four DNA Nucleosides in a Tunneling Gap," Nano Letter, p. 10701075, 2010.

[20] R. H. S. G. A. L. Z. H. M. L. Yuhui He1, "Enhanced DNA Sequencing Performance Through Edge-Hydrogenation of Graphene Electrodes," Advanced Functional Materials, vol. 21, no. 14, p. 26742679, 2011.