International Journal of Scientific & Technology Research

Home About Us Scope Editorial Board Blog/Latest News Contact Us
10th percentile
Powered by  Scopus
Scopus coverage:
Nov 2018 to May 2020


IJSTR >> Volume 9 - Issue 1, January 2020 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616

Design, Synthesis And Biological Activities Of New Alkylated Isatin–Derivatives

[Full Text]



Ruchi Bhatnagar, Dr Jaya Pandey, Dr Deepa Panhekar*



Isatin, Cancer cell-lines, Anti-tumor activity, Anti-fungal activity, Anti-bacterial activity



5-bromo-Isatin, was opted as the base for synthesizing prospective Isatin derivatives which were synthesized for hypothesized biodynamic activities such as anti-bacterial, anti-fungal and antitumor. The synthesized Isatin derivative were characterized by spectrums and were examined for various biological activities.



[1] G. Chen, XJ. Hao, Natural Product Research and Development, 22,356–360,2010.
[2] G. Chen, XJ. Hao, QY .Sun , J, Ding ,Rapid eco-friendly synthesis and bioactivities of 3-nitromethylene-1,3-dihydro-indol-2-one analogues. Chemical Papers, 64(5), 673–377,2010
[3] G. Chen, XJ. Hao, QY .Sun , J, Ding, Synthesis and antitumor activity evaluation of regioselective spiro [pyrrolidine-2, 3'-oxindole] compounds. Heterocyclic Communication, 15(5), 355–361,2009
[4] G. Chen, J. Yang, S. Gao, HP. He, SL. Li, YT .Di, Y. Chang, Y. Lu ,X J.Hao, Spiro[pyrrolidine-2,3'-oxindole] derivatives synthesized by novel regionselective 1,3-dipolar cycloadditions, Mol Divers, 16,151–156 ,2012
[5] G. Chen, J .Zhang, Y. Tag, XJ .Hao, SZ .Mu , icheal addition between Isatin and acrylate derivatives. Letters in Organic Chemistry, 8(9), 614–617, 2011
[6] JFM .Da Silva, SJ .Garden, A.Zda C Pinto ,The chemistry of isatins: a review from 1975 to 1999. The Journal of the Brazilian Chemical Society,12,273–324,2001
[7] S.N Pandeya, S. Smitha, S. Stables, J. P. “Anticonvulsant and sedative-hypnotic activities of N-substituted isatin semicarbazones” Arch. Pharm. Med. Chem. ,4, 129-134,2002.
[8] Pandeya, S. N, D ,Sriram,.; P.Yogeeswari, S.Ananthan, “Antituberculous activity of norfloxacin mannich bases with isatin derivatives” Chemotherapy, 47, 266-269, 2001.
[9] T.D .Brewerton, ,J. Zealberg, J.L ydiard, R. B, Glover, V. Sandler, M,Ballenger, J. C. “CSF isatin is elevated in bulimia nervosa” Biol. Psychiatry, 37, 481-483,1995.
[10] K.L Vine, J.Locke, J. M, Ranson, M, Benkendorff, K, Pyne, S. G. Bremner, J. B. In vitro cytotoxicity evaluation of some substituted isatin derivatives. Bioorg. Med. Chem., 15, 931-938, 2007.
[11] K. L Vine,.; Lidia Matesic; Locke, J. M.; Danielle Skropeta: Recent highlights in the development of Isatin based anticancer agents University of Wollongong, Research Online 2013
[12] J.T. Nguyen, J.A. Wells, ,Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc. Natl. Acad. Sci. U S A, 100, 7533-7538, 2003
[13] Y. Liu, H .Lashuel,. A. Choi, S. Xing, X. Case, A. Ni, J. Yeh, L. A. Cuny, G. D. Stein, R. L. Lansbury, P. T., Jr. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem. Biol., 10, 837-846,2003
[14] G. Bacher, B. Nickel, ,P .Emig, V .anhoefer, U, Seeber, S, Shandra, A, Klenner, T,Beckers, T. D-24851, a novel synthetic microtubule inhibitor, exerts curative antitumoral activity in vivo, shows efficacy toward multidrug-resistant tumor cells, and lacks neurotoxicity. Cancer Res., 61, 392-399,2001.
[15] K. Vine,. L. Locke, J. M. Ranson, M. Pyne, S.G. Bremner, J. B. An investigation into the cytotoxicity and mode of action of some novel N-alkyl-substituted isatins. J. Med. Chem., 50, 5109-5117,2007.
[16] K. Vine,. L.; Matesic, L.; Locke, J. M.; Ranson, M.; Skropeta, D. Cytotoxic and anticancer activities of isatin and its derivatives: a comprehensive review from 2000-2008. Anticancer Agents Med Chem, 9, 397-414,2009.
[17] L. Matesic, J .Locke, M. Bremner, J. B. Pyne, S. G. Skropeta, D. Ranson, M. K .L .Vine, N-phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents. Bioorg. Med. Chem., 16, 3118-3124,2008
[18] N.R. Modi, ,R.J .Shah, M.J .Patel, ,M ,Sutha r, B. Chauhan,. F. Patel, L. J. Design,synthesis, and QSAR study of novel 2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)-Nphenylacetamide derivatives as cytotoxic agents. Medicinal Chemistry Research, 20, 615-625,2011.
[19] P, Singh,.S. Kaur, V .Kumar, P .Bedi,. M .Mahajan, P. Sehar, I. Pal, H. C. Saxena, A. K. Synthesis and in vitro cytotoxic evaluation of N-alkylbromo a nd N-alkylphthalimido-isatins. Bioorg Med Chem Lett.,21, 3017-3020,2011