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IJSTR >> Volume 9 - Issue 1, January 2020 Edition



International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616



Endothelial Dysfunction As A Predictor Of Changes In System A Mother-Placenta-Fetus At The Complicated Pregnancy Gulchekhra Tastanova

[Full Text]

 

AUTHOR(S)

Tashkent State Dental Institute

 

KEYWORDS

vascular endothelium, angiogenesis, vascular endothelial growth factor, nitric oxide, hypochromic anemia, gestosis.

 

ABSTRACT

Were elucidate changes in the NO content, eNOS and iNOS activity, ONO2‾, VEGF,VEGFR-2 rate in the placenta and umbilical cord blood of a newborn after pregnancy with hypochromic anemia and gestosis. In pregnancy, complicated by gestosis and hypochromic anemia, unidirectional disturbances in the NO-system are noted - inhibition of e-NOS activity against the background of NO, i-NOS and ONO2‾expression. The development of DEP in the mother-placenta-fetus system is combined with the expression of ET-1, VEGF and its VEGFR-2 receptor, which can cause the development of structural disorders in the placenta, disorders of angiogenesis in it and as a consequence the development of placental insufficiency, pre – and postnatal fetal pathology.

 

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