IJSTR

International Journal of Scientific & Technology Research

Home About Us Scope Editorial Board Blog/Latest News Contact Us
0.2
2019CiteScore
 
10th percentile
Powered by  Scopus
Scopus coverage:
Nov 2018 to May 2020

CALL FOR PAPERS
AUTHORS
DOWNLOADS
CONTACT

IJSTR >> Volume 9 - Issue 2, February 2020 Edition



International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616



A Simple And Rapid Spectrophotometric Method For Determination Of Organonitrogen Functionalities (Amino Group) And Commercial Drugs Based On It.

[Full Text]

 

AUTHOR(S)

Singh Jasvir

 

KEYWORDS

Manganese (II) acetate; Dimethylsulphoxide (DMSO); Procaine penicillin G and Dopamine hydrochloride.

 

ABSTRACT

Amines serve as starting materials for the preparation of dithiocarbamates and are used largely used in pharmaceutical industry. The reaction of dithiocarbamates with anhydrous manganese (II) acetate in dimethyldulphoxide (DMSO) to form soluble coloured manganese (II) - dithiocarbamate complexes has been made the basis of spectrophotometric (direct colorimetric as well as photometric titrimetric) methods for their determination. The direct colorimetric method consists in adding to DMSO solution of amino compound, an excess of carbon disulphide followed by addition of anhydrous manganese (II) acetate and measuring the resulting colour of metal complex spectrophotometrically at 360 nm (λmax of metal-dithiocarbamets complexes). Alternatively, carbon disulphide was added to the sample solution in DMSO and resulting solution titrated photometrically with standard anhydrous manganese (II) acetate at the respective wavelength. The above spectrophotometric methods have been successfully applied for analysis of amino drugs. The recoveries of procaine penicillin and dopamine hydrochloride from their commercial drug formulations have been found in the ranges 99.0-99.4 and 99.3-100.3% with RSD's in the 0.3-0.4 and 0.2-0.5% respectively

 

REFERENCES

[1] W. Jeffrey Hurst, Journal of Liquid Chromatography., 13(1), pp. 1-23, 1990.
[2] Peace R.W. and Gilani G.S. J AOAC Int., 88(3), pp. 877-87, May-June 2005.
[3] P. Nikitas, A.Pappa-Louisi, J.Liq. chromatogr. Relat. Technol., 32,1527, 2009.
[4] Florian Kugler,, Stephan Graneis,, Pat P.-Y. Schreiter,‡ Florian C. Stintzing, and, and Reinhold Carle, Journal of Agricultural and Food Chemistry, 54 (12), pp. 4311-4318, May 2006.
[5] R. Kronstrand, M. Forsman, M. Roman M , Forensic Sci Int., 283, pp.9-15, Feb. 2018.
[6] A. Navalón, R. El-Khattabi, A. González-Casado, et al., Mikrochim Acta, 130, pp. 261-265, Dec.1999.
[7] L.G haidarova, A.V. Gedmina, E.R. Zhaldak, et al. J Anal Chem., 69: pp. 741, Aug. 2014.
[8] E.M. Mabrouk , R.N. Felaly and E.H. El-Mossalamy, Int. J. Electrochem. Sci., 11,pp. 4892 – 4908, May. 2016.
[9] A. Malik. Hussien, E. Mohamed. W. Adam, Shaza. A.E. Shantier, A.E. Elrasheid, A. Garalnabi and Elrasheed . Gadkariem, Journal of Applied Pharmaceutical Science. 7 (04), pp. 163-167, Apr. 2017.
[10] W. Shaza Shantier, M. E. Adam, S. Rashida Mohamed, E. A. Gadkariem, JIPBS, 4 (3), pp. 67-70, 2017.
[11] F.J. Bandelin andC.R. Kemp, Ind. Eng. Chem. Anal. Ed., 18, pp. Pp. 470, Aug. 1946.
[12] W. Hawkins, D. M. Smith and J. Jr. Mitchell, J. Am. Chem., 66, pp. 1662, 1944.
[13] J.B Johnson. , Anal. Chem., 28, pp. 1977, Dec.1956.
[14] F. Critchfield, J.B. and Johnson., Anal. Chem., 29, pp. 1174, Aug.1957.
[15] J. L. Burguera and M. Burguera J. Anal. At. Spectrom., , 12, (1997), pp. 643-651, 1997.
[16] Pharmacopoeia of India, Published by the Controller of Publications, New Delhi; Vol. I; p. 415, (1985).
[17] International Pharmacopocia, 3rd Edn, Vol. III, p p. 103 (1988).
[18] Pharmacopoeia of India, Published by Controller of Publication, New Delhi, IIIrd Ed, Vol. 1, pp. 415-6 (1985).
[19] A.I. Vogel, :Quantitative Inorgonic Analysis” 3rd Ed., Elbs and Longman, London, pp. 434, (1975)