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IJSTR >> Volume 9 - Issue 2, February 2020 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616

A Simple And Rapid Spectrophotometric Method For Determination Of Organonitrogen Functionalities (Amino Group) And Commercial Drugs Based On It.

[Full Text]



Singh Jasvir



Manganese (II) acetate; Dimethylsulphoxide (DMSO); Procaine penicillin G and Dopamine hydrochloride.



Amines serve as starting materials for the preparation of dithiocarbamates and are used largely used in pharmaceutical industry. The reaction of dithiocarbamates with anhydrous manganese (II) acetate in dimethyldulphoxide (DMSO) to form soluble coloured manganese (II) - dithiocarbamate complexes has been made the basis of spectrophotometric (direct colorimetric as well as photometric titrimetric) methods for their determination. The direct colorimetric method consists in adding to DMSO solution of amino compound, an excess of carbon disulphide followed by addition of anhydrous manganese (II) acetate and measuring the resulting colour of metal complex spectrophotometrically at 360 nm (λmax of metal-dithiocarbamets complexes). Alternatively, carbon disulphide was added to the sample solution in DMSO and resulting solution titrated photometrically with standard anhydrous manganese (II) acetate at the respective wavelength. The above spectrophotometric methods have been successfully applied for analysis of amino drugs. The recoveries of procaine penicillin and dopamine hydrochloride from their commercial drug formulations have been found in the ranges 99.0-99.4 and 99.3-100.3% with RSD's in the 0.3-0.4 and 0.2-0.5% respectively



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