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Antioxidant Activity And Hypoglycemic Potential Of Antidesma Ghaesembilla Gaertn (Phyllantaceae)
[Full Text]
AUTHOR(S)
Maryglen F. Gargantiel, Mafel C. Ysrael
KEYWORDS
Keywords: Antidesma ghaesembilla, Alloxan-induced diabetic rats, antioxidant activity, hypoglycemic, Limit Test, TEAC
ABSTRACT
Abstracts: The present study aimed to: establish a preliminary phytochemical profile and investigate the antioxidant and hypoglycemic potential of the crude methanolic extract of A. ghaesembilla Gaertn (Phyllantaceae). Limit test for acute toxicity (OECD 423) was performed on Sprague-Dawley rats which showed no mortality and is nontoxic up to 5000mg/kg.Scavenging activity revealed an IC5 0of 113 ppm (µg/mL) for DPPH radicals and IC50 estimates of 1724 µmol TEAC/100g DW for ABTS assay. Reducing power of the crude MEAG showed lower activity compared with the standard, Ascorbic acid. Hypoglycemic study showed a percentage decreased in mean glucose level of 56.65%, 55.06% and 54.47% following administration of the crude extract at doses of 400mg, 100mg and 1000mg/kg BW, respectively for 21 days. The data demonstrated that the effect of the extract is not dose-dependent.
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