Role Of Probiotics In The Treatment Of Bacterial Vaginosis
R. S. Vigneshwari, Rambabu, T. Jeyaseelan Senthinath, P. Revathi, S. Deivam A. Uma.
Index Terms: Vaginosis, Probiotic, Lactobacillus rhamnosus and Lactobacillus reuteri.
Abstract: Vaginosis is the most common infection in women of child bearing age. Infections are very common with more than 90 million cases of bacterial vaginosis (BV) worldwide per annum. This study was conducted to assess the efficacy of probiotics as a supplement along with metronidazole in treatment of vaginosis, A total of 50 rural women diagnosed as BV randomly categorized into two groups, Group A patients were treated with metronidazole and probiotic (Lactobacillus rhamnosus and Lactobacillus reuteri) whereas Group B were treated only with metronidazole for five days. Nugent score was recorded before and after the treatment. After initiation of the treatment, there was no change observed on the second and fourth day. On the seventh day symptoms such as itching, odour, discharge were suppressed in the two groups. There was a significant difference in the Nugent score before and after the treatment between group A and group B. (p<0. 05). The Nugent score for group A patient was reduced more than group B, because of the count of Lactobacilli was detected more among group B than group A . This study concluded that the treatment using probiotic along with metronidazole for Bacterial Vaginosis showed the successful effect.
. R. C. R. Martinez, S. A Franchesini, M. C Patta, S. M, Quintana, B. C. Gomes, ,. E. C. P De Martinis, G Reid. ”Improved cure of bacterial vaginosis with single dose of tinidazole(2g), Lactobacillus rhamnosus GR-1,and Lactobacillus reuteri RC-14:a randomized, double blind ,placebo-controlled trial”. Can. J. Microbiol. ,2009;55:133-8.
. V Marcone, E Calzolari, M Bertini, . ”Effectiveness of vaginal administration of Lactobacillus rhamnosus following conventional metronidazole therapy how to lower the rate of bacterial vaginosis recurrences”. New Microbiol,2008;31(3):429-33.
. G Donders, G. Gilbert, E Bosmans. , A Deekermaker, A. Veerecken, B Pharm. B. B Van, B Spitz. ” Pathogenesis of abnormal vaginal flora”. Am. J. Obstet. Gynecol. ,2000;182:872-8.
. G Reid. . J,Burton. “Use of Lactobacillus to prevent infection by pathogenic bacteria. Microbes” Infect,2002;4(3):319-24.
. R Amsel, P. Toten, C. A,Spiegel, K. C Chen, D,Eschenbach, K. K,Holmes. ”Nonspecific Vaginitis:Diagnostic techniques and microbial and epidemiological associations”. Am. J. Med. ,1983;74:14-2.
. M Morris, A Nicoll, I Simms, J Wilson, M Catchpole . ”Bacterial vaginosis :a public health review”. Br. J. Obstet. Gynecol. ,2001; 108;439-50.
. Centres for Disease Control and prevention (CDC). ”Sexually transmitted diseases treatment”. Guidelines MMWR recommendations and reports. , 2002;51:1-80.
. R Hummelen,. J Changalucha, N. L Butamanya, A. A,Cook ,J. D. F Habemma, G Reid. “Lactobacillus rhamnosus GR-1and L. reuteri RC-14 to prevent or cure bacterial vaginosis among women with HIV”. Int. J. Gynecol Obstet. , 2010; 111:245-8.
. R. W Molhor. C. P,Brown,. “Doderlien’s bacillus in the treatment of vaginitis” Am. J. Obstet. Gynecol,1933;25:718-3.
. G Reid. “The scientific basis for probiotic strains of Lactobacillus”. Applied and Environmental Microbiology 1999 ;3763-3766.
. F. R Jones, G Mille, N,Gadea, R Meza, S Leon, J Perez, A. G, Lescano, J. Pajuelo, C. F Caceres, J. D Klausner, T. J Coates. ” NIHM collaborative HIVSTI prevention trial group. Prevalance of bacterial vaginosis among young women in low income populations of coastal Peru”. International journal of STD &AIDS. ,2007;18:188-2.
. G Reid ,A. W Bruce, R. L Cook, M Llano. “Effect on the urogenital flora of antibiotic therapy for urinary tract infection”. Scandinavian Journal of Infectious Diseases, 1990; 22: 43-47.
. G Reid, A. W Bruce , N Fraser, C Heinmann, J. Owen , B Henning. “Oral probiotics can resolve urogenital infections”. FEMS Immunology & Medical Microbiology, 2001; 30: 49-52.
. K Anukam, G Osazuwa, A. W Bruce, G Reid, I. Ahonkhai, M Ngwu, G. Osemene. “Augmentation of antimicrobial metronidazole therapy of bacterial vaginosis with oral probiotic L. rhamnosus GR-1 and L. reuteri RC-14: randomized ,double-blind, placebo controlled trial”. Microbes and Infection. ,2006;8(6):1450-4.
. L Perticevic,. A Witt. ” The role of Lactobacilluscaseirhamnosus Lcr35 in restoring the normal vaginal flora after antibiotic treatment of bacterial vaginosis”. BJOG. ,2008;115:169-74.
. G. E Gardiner, C Heinemann, A. W Bruce, D Beurman, G Reid. “Persistence of L. fermentum” 2002;9;192-196.