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IJSTR >> Volume 9 - Issue 3, March 2020 Edition



International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616



EXPRESSION IN CERVICAL CELLS OF WOMEN IN INDONESIA, A PRELIMINARY STUDY

[Full Text]

 

AUTHOR(S)

Elfira Sutanto, Elsha Dwi Anggun Rachmadhany, Ita Tazkiatul Izzati Mustopa, Elrian Syaputra, Monica Dwi Hartanti

 

KEYWORDS

Cervical cancer, DNA, HMGA2, HPV, Integration, KLF5, KLF12, SEMA3D.

 

ABSTRACT

Cervical cancer is the major cause of death of women in Indonesia after breast cancer. It is believed that the integration of Human Papilloma Virus plays a critical role in the development of cervical cancer. A recent study discovered "hot spots" contained candidate genes that are linked to the integration of DNA HPV to the host's genome. This preliminary study aims to investigate the expression of these genes in HPV-uninfected cervical cells. Most of the genes were expressed in HPV-uninfected cervical cells and their expression levels were significantly different from each other qualitatively and quantitatively, suggesting that these genes might have an important role in maintaining a normal function of cervical cells. Perturbation in the expression level of these genes might be linked to the developing of pathological conditions, such as cervical cancer.

 

REFERENCES

[1] World Health Organization, “Cervical Cancer Screening in Developing Countries, Report of a WHO Consultation,” https://apps.who.int/iris/handle/10665/42544. 2002.
[2] National Institute of Health Research and Development, Indonesian Ministry of Health, “Basic Health Research 2013,” www.depkes.go.id/resources/download/general/Hasil%20Riskesdas%202013.pdf. 2013.
[3] J. Doorbar and H. Griffin, "Refining Our Understanding of Cervical Neoplasia and Its Cellular Origins," Papillomavirus Res., vol. 7, pp. 176-179, available at doi:10.1016/j.pvr.2019.04.005, Jun. 2019.
[4] E.J. Crosbie, M.H. Eistein, S. Franceschi, H.C. Kitchener, “Human Papillomavirus and Cervical Cancer,” The Lancet, vol. 382, no. 9895, pp. 889-899, Sep. 2013.
[5] M.A. Stanley, M.R. Pett, N. Coleman, “HPV: from Infection to Cancer," Biochem Soc Transactions, vol. 35, pp. 1456-1460, Dec. 2007.
[6] N. Wentzensen, S. Vinokurova, M. Von Knebel Dowberitz, "Systematic Review of Genomic Integration Sites of Human Papillomavirus genomes in Epithelial Dysplasia and Invasive Cancer of the Female Lower Genital Tract," Cancer Res, vol. 64, no. 11, pp. 3878-3884, Jun. 2004.
[7] Z. Hu, D. Zhu, W. Wang, W. Li, W. Jia, X. Zeng, W. Ding, L. Yu, X. Wang, L. Wang, H. Shen, C. Zhang, H. Liu, X. Liu, Y. Zhao, X. Fang, S. Li, W. Chen, T. Tang, A. Fu, Z. Wang, G. Chen, Q. Gao, S. Li, L, Xi, C. Wang, S. Liao, X. Ma, P. Wu, K. Li, S. Wang, J. Zhou, J. Wang, X. Xu, H. Wang, D. Ma, “Genome-wide Profiling of HPV Integration in Cervical Cancer Identifies Clustered Genomic Hot Spots and a Potential Microhomology-mediated Integration Mechanism,” Nat Genet, vol. 47, no. 2, pp. 158-163, Feb. 2015.
[8] D. Ma, L.Y. Chang, S. Zhao, J.J. Zhao, Y.J. Xiong, F.Y. Cao, Lu Yuan, Q Zhang, X.Y. Wang, M.L. Geng, H.Y. Zheng, O. Li, “KLF5 Promotes Cervical Cancer Proliferation, Migration, and Invasion in a Manner Partly Dependent on TNSRF11a,” Sci Rep, vol. 7, no. 1, pp. 15683, Nov. 2017.
[9] X. Gao, M. Dai, Q. Li, Z. Wang, Y. Lu, Z. Song, ”HMGA2 Regulates Lung Cancer Proliferation and Metastasis,“ Thorac Cancer, vol. 8, no. 5, pp. 501-510, Sep. 2017.
[10] Z. Wang, M. Ding, N. Qian, B. Song, J. Yu, J. Tang, J. Wang, “Decreased Expression of Semaphoring 3D is Associated with Genesis and Development in Colorectal Cancer,” World Journal of Surgical Oncology, vol. 15, no. 67, pp. 4-8, Mar. 2017.
[11] N. Godin-Heymann, S. Brabetz, M.M. Murillo, M. Saponaro, C.R. Santos, A. Lobley, P. East, P. Chakravarty, N. Matthews, G. Kelly, S. Jordan, E. Castellano, J. Downward, “Tumour-suppression function of KLF12 through regulation of anoikis,” Oncogene,” vol.. 35, no. 25, pp. 3324-3334, Jun. 2016.
[12] I.I. Daud, M. E. Scott, "Validation of Reference Genes in Cervical Cell Samples from Human Papillomavirus-Infected and –uninfected Women for Quantitative Reserve Transcription-PCR Assays," Clin Vaccine Immunol., vol. 15, no. 9, pp. 1369-1373, Sep. 2008.
[13] O. Reich, S. Regauer, W.G. McCluggage, C. Bergeron, C. Redman, “Defining the Cervical Transformation Zone and Squamocolumnar Junction: Can We Reach a Common Colposcopic and Histologic Definition?,” Int J Gynecol Pathol, vol. 36, no. 6, pp. 517-522, Nov. 2017.
[14] J.E. Martens, F.M. Smedts, D. Ploeger, T.J. Helmerhorst, F.C. Ramaekers, J.W. Arends, A.H. Hopman, “Distribution Pattern and Marker Profile Show Two Subpopulations of Reserve Cells in the Endocervical Canal,” Int J Gynecol Pathol, vol. 28, no. 4, pp. 381-388, Jul. 2009.
[15] J.M. Pattison, V. Posternak, M.D. Cole, "Transcription Factor KLF5 Binds Cyclin E1 Polymorphic Intronic Enhancer to Center Increased Bladder Cancer Risk," Mol Cancer Res, vol. 14, no. 11, pp. 1079-1086, Nov. 2016.
[16] L. Jia, Z. Zhou, H. Liang, J. Wu, P. Shi, F. Li, "KLF5 Promotes Breast Cancer Proliferation, Migration and Invasion in Part by Upregulating the Transcription of TNFAIP2," Oncogene, vol. 35, no. 16, pp. 2040-2051, Apr. 2016.
[17] A.B. Bialkowska, Y. Liu, N.O. Nandan, V.W. Yang, “A Colon Cancer-derived Mutant Krüpple-like Factor 5 (KLF5) is Resistant to Degradation by Glycogen Synthase Kinase 3 and the E3 Ubiquitin Ligase F-box and WD Repeat Domain-Containing 7α,” J. Biol Chem, vol. 289, no. 9, pp. 5997-6005, Feb. 2014.
[18] Y.K.T. Murakami, “Paroxysmal Nocturnal Hemoglobinuria,” Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms, L McManus, R. Mitchell, eds., Academic Press, pp. 1462–1470, 2014.
[19] S. Peluso, G. Chiappetta, “High-mobility group A (HMGA) Proteins and Breast Cancer,” Breast Care, vol. 5, no. 2 pp. 81-85, 2010.
[20] Y. Luo, W. Li, H. Liao, “HMGA2 Induces Epithelial-to-mesenchymal Transition in Human Hepatocellular Carcinoma Cells,“ Oncol Lett., vol. 5, no. 4, pp. 1353-1356, Apr. 2013.
[21] L. Wang, H. Shen, D. Zhu, B. Feng, L. Yu, X. Tian, C. Ren, C. Gao, X. Li, D. Ma, Z. Hu, H. Wang, “Increased High Mobility Group A 2 Expression Promotes Transition of Cervical Intraepithelial Neoplasm into Cervical Cancer,” Oncotarget, vol. 9, no. 8, pp.7891–7901. Jan. 2018.
[22] X. Gao, M. Dai, O. Li, Z. Wang, Y. Lu, Z. Song, “HMGA2 Regulates Lung Cancer Proliferation and Metastasis,” Thorac Cancer, vol. 8, no. 5, pp. 501-510, Sep. 2017.
[23] M.J. Ham, B.C. Kirchmaier, W. Herzog, “Sema3d Controls Collective Endothelial Cell Migration by Distinct Mechanisms via NRP1 and PlxnD1,” Journal Cell Biology, vol. 215, no. 3, pp. 415, Nov. 2016.
[24] M. Rehman, L. Tamagnone, “Semaphorins in Cancer: Biological Mechanisms and Therapeutic Approaches,” Semin Cell Dev Biol., vol. 24, no. 3, pp. 179-180 2013.
[25] R. Mishra, D. Kumar, D. Tomar, G. Chakraborty, S. Kumar, G.C. Kundu, “The Potential of Class 3 Semaphorins as Both Targets and Therapeutics in Cancer,“ Expert Opin Ther Targets, vol. 19, no. 3, pp. 427-442, Mar. 2015.
[26] Z. Wang, M. Ding, N. Qian, B. Song, J. Yu, J. Tang, J. Wang, “Decreased Expression of Semaphorin 3D is Associated with Genesis and Development in Colorectal Cancer,” World Journal of Surgical Oncology, vol. 15, no. 6, pp. 4-8, Mar. 2017.
[27] K. Foley, A.A. Rucki, Q. Xiao, D. Zhou, A. Leubner, G. Mo, J. Kleponis, A.A. Wu, R. Sharma, Q. Jiang, R.A. Anders, C.A. lacobuzio-Donahue, K.A. Hajjar, A. Maitra, E.M. Jaffee, L. Zheng, "Semaphorin3D Autocrine Signaling Mediates the Metastatic Role of Annexin A2 in Pancreatic Cancer," Sci Signal, vol. 8, no. 388, pp. ra77, available at doi: 10.1126/scisignal.aaa5823, Aug. 2015.
[28] A. Imhof, M. Schuierer, O. Werner, M. Moser, C. Roth, R. Bauer, R. Buettner, “Transcriptional Regulation of the AP-2alpha Promoter by BTEB-1 and AP-2rep, a Novel wt-1/egr-related Zinc Finger Repressor,” vol. 19, no. 1, pp. 194-204, Jan. 1999.