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IJSTR >> Volume 9 - Issue 3, March 2020 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616

The Role Of Interleukin 7 Receptor Alpha (Il7ra) Rs6897932 Gene Polymorphism In The Development Of Breast Cancer Among Women In Kerala Population, South India.

[Full Text]



Mohthash MT, Sunil Kumar Shah, Anand Thirupathi



Breast cancer, IL7RA polymorphism, rs6897932.



Interleukin-7 (IL-7) has always been found to play a significant role in the development of lymphoid cell as well as in its maintenance. In breast cancer (BC) subjects, through the activation of JAK1/3-STAT5 and PI3K/AKT pathways, IL-7 promotes the growth of tumor cells. The current study aims to find the possible association of IL7RA (rs6897932) polymorphism with the susceptibility of BC among the diverse population of Kerala, South India. A case-control study was conducted at two health care centers in Kerala, South India involving 112 breast cancer patients (females) and 112 healthy controls (females). Genetic analysis was performed to detect IL7RA (rs6897932) polymorphism e employing polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Odds ratio (OR) with 95% class interval (CI) were used to evaluate the relationship of IL7RA (rs6897932) polymorphism with BC susceptibility. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS; version 21.0) software and Medcalc software (version 16.4.3). The frequency distribution of IL7RA (rs6897932) polymorphism was found to be different between case and control groups significantly indicating IL7RA gene could play an important role in the pathogenesis of BC among South Indian population. The rs6897932 homozygous mutant CC genotype (OR=3.04; 95% CI =1.46-6.32; p=0.002), as well as the C allele (OR= 2.59; 95% CI =1.43-4.70; p=0.001), was found to increase the risk of BC among the studied South Indian (Kerala) subjects. The present study provided evidence regarding the role of IL7RA (rs6897932) polymorphism in the development of breast cancer among the South Indian population (Kerala) and that IL7RA gene may play distinct roles in breast carcinogenesis. The present study results need to be validated by further advanced and prospective studies involving larger sample sizes.



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