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IJSTR >> Volume 4 - Issue 8, August 2015 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616

Lipids And Hscrp As Markers Of Coronary Heart Disease Risk In HIV Infected Adults

[Full Text]



Danai Tavonga Zhou, Vitaris Kodogo, Munyaradzi Dzafitita, Olav Řktedalen, Rudo Muswe, Babill Stray-Pedersen



Index Terms: antiretroviral therapy, cardiovascular disease, HIV, hsCRP, inflammation, lipid,



Abstract: Life-expectancy among HIV-infected patients has risen due to use of antiretroviral drugs. However there are new concerns as accompanying metabolic and morphologic changes predispose HIV-infected individuals to cardiovascular disease. Progression of cardiovascular disease is a slow process marked by both changes in lipid levels and low grade systemic inflammation, assessed using highly sensitive C-reactive protein (hs-CRP). The aim of the study was to evaluate the risk of cardiovascular disease in HIV-infected patients using lipids and hs-CRP levels. Serum and plasma samples were collected from HIV-infected adults who were antiretroviral therapy-experienced (n=87) or antiretroviral therapy-naďve (n=10). Samples were analysed using Siemens® Dimension Xpand analyser. Mean hs-CRP for all participants suggested that they had some risk of cardiovascular disease in spite of antiretroviral therapy history. Of all 97 participants, 57.7% had elevated hs-CRP levels (>3mg/dL) suggesting high risk, 26.8% had levels between 1 and 3mg/dL (average risk) and 34% had levels below 1mg/dL (low risk). Lipid levels were normal in all participants and there was no correlation between hs-CRP and lipid levels. There was no significant difference in hs-CRP levels by sex, age and antiretroviral therapy history. Elevated hs-CRP levels of participants suggest that HIV-infected patients may be at risk of cardiovascular disease through low-grade inflammation.



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