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International Journal of Scientific & Technology Research

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IJSTR >> Volume 9 - Issue 4, April 2020 Edition



International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616



GASTRO-RETENTIVE DRUG DELIVERY SYSTEM FOR PROLONG DRUG RELEASE: A BLANKET REVIEW

[Full Text]

 

AUTHOR(S)

Patil Nilesh S, Salunkhe Kishor S, Chavan Machindra J, Chintamani Ravindra B

 

KEYWORDS

Gastro Retentive Drug Delivery System, GRDDS, GIT, Gastric Emptying, Stomach Physiology, Gastric Motility, Gastric Residence time

 

ABSTRACT

The purpose of this review article is to evaluate the fact that it’s worth to research in the development and of the drugs that are being formulated to have greater gastro- retentive period in the stomach which enhances the therapeutic purpose of the drug for the proper site with desired concentration. This also indicates a reduced administering of the dosages. There have been quite a lot of techniques developed to achieve the prolonged gastric emptying from stomach to the small intestine. Presently, pharmacological experiments have been able to formulate drugs adapting specific methods for the targeted gastric retention time period. The techniques in use as per the demand are low density systems, high density systems, magnetic systems, muco- adhesive systems, super porous hydrogel systems (cited as per the recent available information). The detailed study on the prolonged residence time for the drug dosage forms focusses on the floating drug delivery systems (FDDS) as an efficient form. Floating systems are hydro- dynamically controlled systems that have low density and are buoyant enough to float over the contents of the stomach for a long time and without affecting the gastric emptying rate. The drug is released at a rate which is desired and customized. There had been much speculations about GRDDS in the past but now purposeful and extensive researchers offer sophisticated formulation of dosage forms that are customized for delayed gastro retention time.

 

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