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IJSTR >> Volume 9 - Issue 4, April 2020 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616

In Vitro Correlation Studies On Anticancer, Antioxidant Activity And Phenolic Content Of Green Marine Seaweeds From Gulf Of Mannar

[Full Text]



Maheswari A, Dr. Salamun DE



Green marine macro algae, antioxidant activity, anticancer activity.



Large number of existing studies have emphasized that thousands of natural polyphenols are represented from plant domain, occupying almost 70% of the globe, ocean incorporates enormous number of novel products with unique biological activities that may be useful in cancer drug development. Therefore four marine seaweeds were isolated, identified authenticated and they were analyzed for various antioxidant properties and the percentage of reaction in cell viability was also calculated to determine the potentiality of the secondary metabolites. The free radical scavenging activity was determined using DPPH and FRAP, and anticancer activity by MTT against HepG2 cancer cell line. It is evident from the results, among all four marine algal seaweeds, C.racemosa (46.32±0.55%) showed highest scavenging activity in DPPH and C.verticillata (61.83±0.012μM) in FRAP assay. In addition, a significant anticancer activity was observed in ethanolic crude extracts of C.scalpelliformis (78.52%) and C.verticillata (85.69%) of cell viability at 25μg/ml. Hence, the present study confirms that the green marine macro algae possess antioxidant and anticancer properties. Further analysis has to be carried out to determine the various bioactive compounds responsible for these biological functions.



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