IJSTR

International Journal of Scientific & Technology Research

IJSTR@Facebook IJSTR@Twitter IJSTR@Linkedin
Home About Us Scope Editorial Board Blog/Latest News Contact Us
CALL FOR PAPERS
AUTHORS
DOWNLOADS
CONTACT
QR CODE
IJSTR-QR Code

IJSTR >> Volume 4 - Issue 5, May 2015 Edition



International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616



Influence Of Sympathetic Hyperactivity And Levels Of Endothelin-1 In Hypertension To Pregnancy And Small For Gestational Age (SGA)

[Full Text]

 

AUTHOR(S)

Pesta Corry Sihotang

 

KEYWORDS

Index Terms: PIH, CPT, ET-1, SGA

 

ABSTRACT

Abstract: Pesta Corry Sihotang. Effect of sympathetic hyperactivity, Endothelial Dysfunction Due to Hypertension and Small for gestational age (SGA). In Indonesia, hypertension due to pregnancy (Pregnancy Induced Hypertension) range from 5-10% of all pregnancies. This is a major cause of death, after bleeding. Hypertension due to pregnancy can be Preeclampsia and eclampsia, if not handled appropriately. This study aimed to prove the influence of the sympathetic hyperactivity, endothelial dysfunction on the incidence of PIH and SGA. The study design is nested cohort. Methods and ways of working: 30 pregnant women who were willing to participate in this study examined after signing the agreement / informed consent. Research subjects are grouped into groups of PIH and Normal and followed until delivery. In conclusion there was a significant difference between the incidence hype-reactor and hypo-reactor second trimester with the incidence of PIH and normotensive with Chi-Square P <0.05 against the incidence of hypertension. While the risk of PIH on hype-reactor group in the second trimester has RR 3.66 (CI 1.04 to 12.9), while the results of the third trimester there is a difference between having hype-reactor and hypo-reactor with RR of 5.83 (CI 1.37 to 24.6). Results ET-1 shows the differences in levels of endothelin in the third trimester with PIH and normotensive patients, namely (R = 0.38 p = 0.038 and R = 0.49, p = 0.005). Furthermore, in the third trimester relationship with the incidence of PIH R = 0.74 or 0.01 p in the end there are differences between the mean levels of ET-1 in the third trimester between PIH and normotensive group (p <0.05). Recommendations CPT (Cord Pressure Test) is a tool that can be used to predict the incidence of hypertension in pregnancy, especially in the second trimester, while the results of Elisa can predict the incidence of hypertension in pregnancy.

 

REFERENCES

[1] Abdurazzak, G., Dhyanti, S., Wijnyosastro, GH., Moegini, E.M., Fadilah. Difference of Arachidonic Acid-eicosapentaenoic acid on Preeclampsia compared with Normal Pregnancies in : XI Congress of obstetrics and gynaecology, 1 – July 3, 2000; Denpasar. PG. 1 –.

[2] Bennet, V. Ruth. 1997. Myles Texbook For Midwivice 9, twelfth edition. University of Greenwich – United Kingdom

[3] Chalid, t. Maisuri, 2002. The relationship of the Tumor Necrosis Factor-Alpha and Endothelin-1 in Maternal Serum Fetal Growth with late on Preeclampsia is heavy.

[4] Conrad, K.P., Benyo,, d.f. 1997. Placental Cytokines and the pathogenesis of preeclamsia;Am.J.Reprod Immunol. 1997; 37: 240 – 9

[5] Enkin, Muraay. 2000. A Guide to effective care in pregnancy and childbirth third edition.Oxford University Press-United Kingdom

[6] Siregar, p. 2002. Hypertension In Pregnancy.Information centre and Publishing Part Of The Faculty of medicine University of Indonesia in Jakarta.

[7] Sweet, Betty. R. 1997. Mayes, A Texbook Midwifery For Midwives, twelfh edition university of greewich –The United Kingdom