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IJSTR >> Volume 7 - Issue 5, May 2018 Edition



International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616



Toxicological Studies On Heavy Metal Bioaccumulation And Oxidative DNA Damage In Residents Of An Oil Producing Area

[Full Text]

 

AUTHOR(S)

Ifenkwe John Chimerenka, Nwanjo Harrison Ugochukwu, Nwosu Dennis Chimezie, Ogbotobo Roland Fiezibe

 

KEYWORDS

Heavy Metal, Bioaccumulation, Oxidative Stress, DNA Damage Contaminants Reactive Oxygen Species.

 

ABSTRACT

This study was carried out on blood samples collected from 200 residents each from Igbeta-Ewoama (Oil Producing Area) and Odi (Non-Oil Producing Area) both in Bayelsa State, Nigeria, to determine the blood levels of Cadmium, Chromium, Lead, Mercury and Selenium and also the oxidative DNA damage marker 8-Hydroxy-2-deoxyguanosine (8-OHdG). Blood samples were also analyzed for WBC, Hb, platelets, prothrombin time and serum concentrations of AST, ALT, albumin, ALP, bilirubin, gamma GT, total protein, sodium, potassium, chloride, bicarbonate, urea and creatinine. Residents in Igbeta-Ewoama had the highest blood levels of Mercury, Lead, Selenium, Cadmium, Chromium and 8-OHdG and they were all significantly different at p<0.05. Residents in Igbeta-Ewoama had the highest mean values of all the measured liver and kidney functions parameters with the exception of albumin, total protein, sodium, chloride and bicarbonate. These values were all statistically different at P<0.05. There was significant difference in the levels of Hb, WBC and Platelet while the length of bleeding time was prolonged in the residents of Igbeta-Ewoama community. The findings of this study suggest that the probability of occurrence of diseases associated with metal toxicity and oxidative stress might be higher among residents in the oil producing area.

 

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