IJSTR

International Journal of Scientific & Technology Research

Home About Us Scope Editorial Board Blog/Latest News Contact Us
0.2
2019CiteScore
 
10th percentile
Powered by  Scopus
Scopus coverage:
Nov 2018 to May 2020

CALL FOR PAPERS
AUTHORS
DOWNLOADS
CONTACT

IJSTR >> Volume 10 - Issue 5, May 2021 Edition



International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616



The Potency Of Pregelatinized Red Bean (Phaseolus Vulgaris L.) Flour On The Improvement Of Lipid Profiles Of Hypercholesterolemic Rats

[Full Text]

 

AUTHOR(S)

Waluyo, Yudi Pranoto, Sardjono, Yustinus Marsono

 

KEYWORDS

Pregelatinization, red bean flour, resistant starch, lipid profile, bile acids, hypercholesterolemic.

 

ABSTRACT

The pregelatinization process of red bean (RB) using heating-cooling combination method could improve resistant starch (RS) levels which had the potential to lower cholesterol (hypocholesterolemic). The aim of this study was to determine the effect of pregelatinized RB flour diet on lipid profiles in vivo and to assess the in vitro bile binding capacity. Thirty rats were divided into 5 groups, namely groups of normal rats on standard diet, hypercholesterolemic rats with standard diet (negative control), hypercholesterolemic rats with standard diet were given statin (positive control), hypercholesterolemic rats were on a diet of natural RB flour and hypercholesterolemic rats were on diet of pregelatinized RB flour. Lipid profile analysis was carried out periodically every week during a dietary intervention period of 4 weeks. The bile binding capacity of natural RB flour and pregelatinized RB flour was tested by the method of Soral et al. It was found that pregelatinized RB flour diet reduce total cholesterol levels (-43.66%), LDL cholesterol (-57.80%), triglycerides (-16.32%), and increase HDL cholesterol levels (171.50%). And reduce the AIP (-72.63%). The in vitro study showed that the pregelatinized RB diet was able to bind 13.61% of cholic acid and 48.02% deoxicolic acid. To concloude, pregelatinized RB flour could improve lipid profile and decrease AIP. The possible mechanism was due to the bile acid binding capacity of the pregelatinized RB flour.

 

REFERENCES

[1] Athur, S.L., 2009. Dyslipidemia and risk of coronary heart Disease :
[2] Role of lifestyle approaches for its management American Journal of
[3] Lifestyle Medicine, 3(4):257-273.
[4] Nie, Q., Hu, J., Gao, H., Fan, L., Chen, H., and Nie, S. 2017.
[5] Polysaccharide from Plantago asiatica L. attenuates hyperglycemia, hyperlipidemia and affects colon microbiota in type 2 diabetic rats. Food Hydrocolloids xxx (2017) 1- 9.
[6] Anonim. (2018). World Health Organization. (2018). The Top 10 causes
[7] of death. Accessed from https://www.who.int/news-room/fact-
[8] sheets/detail/the-top-10-causes-of-death. (December 20, 2019).
[9] Aman, A.M., Soewondo, P., Soelistijo, S.A, Arsana, P.M., Wismandari,
[10] Zufri, H and Rosandi, R. (2019). Guidelines for the management of
[11] dyslipidemia in Indonesia-2019. PB. Perkeni
[12] Arsana, PM., Rosandi, R., Manaf.A, 2015. Guidelines for the
[13] management of dyslipidemia in Indonesia-2015. PB. Perkeni
[14] Rangika, B. S., Dayananda, P. D., & Peiris, D. C. (2015).
[15] Hypoglycemic and hypolipidemic activities of aqueous extract of flowers from Nycantus arbor-tristis L. in male mice. BMC Complementary and Alternative Medicine, 15.
[16] Siriangkhawut, M., Tansakul., Uchaipichat, V. 2017.
[17] Prevalence of potential drug interactions in Thai patiens receiving simvastatin: The causality assessment of musculoskeletal adverse events induced by statin interaction. Saudi Pharmaceutical Journal2017; 25:823–9.
[18] Marsono, Y. (2004). Dietary fiber in a nutritional science perspective.
[19] Professor's Inauguration Speech. UGM, Yogyakarta.
[20] Sayago-ayerdi, Mateos, R., Ortiz-Basurto, RI., Largo,C, Serrano, J.,
[21] Granado- Serrano, AB, Sarria, B, Bravo, L, Tabernero, M. (2014). Effects
[22] Figures may only appear in color for certain journals. of Consuming
[23] Diets Containing Agave Tequilana DF and Jamaica Food Chemistry
[24] 148: 54-59.
[25] Stephen, A.M., Champ, M,M,J., Cloran, S.J., Fleith, M., Lieshout, L.V.,
[26] Mejborn, H., and Burley, V.J. 2017. Dietary Fibre in Europe: current state of knowledge on definitions, Sources, recommendations, intakes and relationships to healts. Nutrition Research Reviews 30, 149–190
[27] Niroumand, S., Khajedaluee, M., Rezaiyan, M.K.,
[28] Abrishami, M., Juya, M., Khodaee, G., Dadgarmoghaddam, M. 2015. Atherogenic Index of Plasma (AIP): A marker of cardiovascular Disease. Med J Islam Repub Iran 2015. Vol. 29:240
[29] Dobiasova and Frohlich. 2001.The plasma parameter log
[30] (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL). Clin Biochem. 2001 Oct;34 (7):583-8
[31] Bae, I. Y., Lee, S., Kim, S. M. dan Lee, H. G. (2009). Effect of partially
[32] hydrolysed oat β- glucan on the weight gain and lipid profile of mice.
[33] Food Hydrocolloids 23: 2016-2021
[34] Surampudi, P., Enkhmaa, B., Anuurad, E., and Berglund L.2016. Lipid
[35] Lowering with soluble dietary fiber. Curr Atheroscler Rep (2016) 18:75
[36] Waluyo, Pranoto, Y., Sardjono, Marsono, Y. (2021).
[37] Increasing Resistant Starch and Characteristics of Pregelatinized Red Bean Flour (Phaseolus vulgaris L.) Heat-Cooling Combination Method
[38] Reeves, P.G., Nielsen, F.H. dan Fahey Jr, G.C. (1993). AIN-93 purified
[39] Diets for laboratory rodents: final report of the American Institute of
[40] Nutrition Ad Hoc WritingCommittee on the reformulation of the AIN-
[41] 76A rodent diet. Journal of Nutrition, Committee Report: 1939-1951
[42] Serougne, C., Felgines, C., Ferezou, J., Hajri, T., Bertin, C.,
[43] dan Mazur, A. (1995). Hypercholesterolemia Induced by Cholesterol- or Cystine-Enriched Diets is Charaterized by Different Plasma Lipoprotein and Apolipoprotein Concentrations in Rats. J. Nut 125: 35-41
[44] Ihedioha, J.I., Noel-Uneke, Q.A., Ihedioha, T.E. (2013). Reference
[45] values for the serum lipid profile of albino rats (Ratus norvegicus) of
[46] varied ages snd sexes. Comp Clin Pathol 22: 93-99.
[47] Deeg, R dan Ziegenhorn, J. (1983). Kinetic Enzymatic Method For
[48] Automated. Determination of Total Cholesterol in Serum. Clinical
[49] Chemistry 29 1798-1802
[50] Richmond, W., 1973. Preparation and Properties of acholesterol
[51] oxidase from Nocardia, sp. and its application to the enzymatic assay
[52] of total cholesterol in serum. Clin. Chem., 19:1350-1356.
[53] Lopes-Virella, M.F., P. Stone, S. Ellis and J.A. Colwell, 1977.
[54] Cholesterol determination in high-dencity lipoprotein separated by
[55] three different method. Clin. Chem., 23:882-884.
[56] McGowan, M.W., J.D. Artis, D.R. Strandberg and B. Zak, 1983. A
[57] peroxidase coupled method for the colorimetric determination of
[58] serum triglycerides. Clin. Chem., 29:538-542.
[59] Rubenfire M, Coletti AT, and Mosca L.1998. Treatment strategies for
[60] management of serum lipids: lessons learned from lipid metabolism,
[61] recent clinical trials, and experience with the HMG CoA reductase
[62] inhibitors. Prog Cardiovasc Dis. 1998 (2):95-116
[63] Niroumand, S., Khajedaluee, M., Rezaiyan, M.K., Abrishami, M., Juya,
[64] M., Khodaee, G., Dadgarmoghaddam, M. 2015. Atherogenic Index of
[65] Plasma (AIP): A marker of cardiovascular Disease. Med J Islam
[66] Repub Iran 2015. Vol. 29:240
[67] Soral-Smietana, M., Wronkowska, M. dan Amarowicz, R. (2000).
[68] Health Promoting Function of Wheat or Potato Resistant Starch
[69] Preparations Obtained by Physico-Biochemical Process.
[70] Mishra, P.K., Tripathi, J., Gupta, S., Variyar, P.S. 2015. Effect of cooking
[71] on aroma profile of red kidney beans (Phaseolus vulgaris) and
[72] correlation with sensory quality. Food Chemistry 215 (2017) 401–409
[73] Grundy, S.M., Cleeman, J.I., Merz., C.N.B., Brewer, H.B., Clark, L.T.,
[74] Hunninghake, D.B., Pasternak, R.C., Smith, S.C. dan Stone, N.J. (2004).
[75] Implications of recent clinical trial for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Coordinating Committee of the National Cholesterol Education Program. Arterioscler. Thromb. Vasc. Biol., 24:e149-161
[76] Higgins, J.A., Higbee, D.R., Donahoo, W.T., Brown, I.L., Bell, M.L. dan
[77] Bessesen, D.H. (2004). Resistant Starch consumption promotes lipid
[78] oxidation. Nutr. Metabolism 1: 8.
[79] Damat, Y. Marsono, Haryadi, and Cahyanto, M.N.2008.
[80] Hypocholesterolemic and hypoglicemic effects of butyrylated arrowroot starch on Sprague Dawley rats. Indonesian Pharmacy Magazine, 19 (3), 2008
[81] Marsono, Y., 2001. Resistant Starch: Formation, metabolism and
[82] nutritional aspects (Review). Agritech Vol. 18, 4: 29 – 35
[83] Kristensen, Jensen, MM.G., Aarestrup, J Kristina EN Petersen, K.E.,
[84] Søndergaard, L Mikkelsen, M.S and Astrup, A.2012. Flaxseed dietary
[85] fibers lower cholesterol and increase fecal fat excretion, but magnitude
[86] of effect depend on food type . Nutrition & Metabolism 9:8
[87] Matsuda, H., Kumazaki, K., Otokozawa, R., Tanaka, M.,Udagawa, E.,
[88] and Shirai, T. 2016. Resistant Starch suppresses postprandial
[89] hypertriglyceridemia in rats. Food Research International xxx (2016)
[90] xxx–xxx
[91] Capuano, E. 2017. The behavior of dietary fiber in the gastrointestinal
[92] tract determines its physiological effect. Critical reviews in food
[93] science and nutrition 2017, vol. 57, no.16, 3543–3564
[94] Katzung, B.G., Masters, S.B., dan Trevor, A.J. (2012). Basic and clinical.
[95] pharmacology. 12th edition. McGrawHill Medical. NewYork
[96] Marsono, Y., Putri, R.G. & Arianti, E.D. (2020). The Effects of
[97] Replacement of Dietary Fiber with FiberCreme™ on Lowering Serum Glucose and Improvement of Lipid Profile in Hypercholesterolemia-Diabetic Rats and Its Mechanism. Pakistan Journal of Nutrition. 19(4):204-211
[98] Barua, L., Faruque, M., Banik, P.C., dan Ali, L. 2019. Atherogenic Index
[99] of Plasma and its association with Cardiovascular disease risk factor