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IJSTR >> Volume 10 - Issue 5, May 2021 Edition



International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616



Gel Formulation Of Ethanol Extracts Of Durian Fruit Skin (Durio Zibethinus) As An Antifungal To Candida Albicans And Trichophyton Mentagrophytes

[Full Text]

 

AUTHOR(S)

Yuli Wahyu Tri Mulyani, Siti Nurjanah, Samsuar, Laila Susanti

 

KEYWORDS

Antifungal,Candida albicans,Durian Skin, Ethanol Fraction, Trichopyhton mentagrophytes

 

ABSTRACT

Durian is a fruit that Indonesian people demand, but environmental problems arise when the durian season comes due to unutilized durian skin wastes. This research harnesses the waste of durian skin which is then processed into a formulation of gel as an antifungal. The aim of this study is to prove that this gel formulation can inhibit the growth activity of Candida albicans and Trichophyton mentagrophytes. The maceration method was used for extraction processes with 70% of ethanol solvents. Extraction results were then made of gel formulations and separated into several concentrations, formulations 1 (15%), formulation 2 (20%), formulation 3 (25%), as well as base gel as a negative control and gel containing ketoconazole 2% as a positive control. Results show that the gel of durian skin extracts provided a weak inhibition zone at the highest concentration of 25% with an average 5.70 mm ± 0.27 for Candida albicans and did not give any inhibition zone on all gel formulations for Trichophyton mentagrophytes. Preparations of gel formulations were evaluated physically including organoleptic observation resulting F1 in brown, F2 in dark brown and F3 in blackish brown. Homogeneity tests show that all formulations were homogeneous, marked by no appearance of coarse grains. The pH value of all formulations in accordance with the cosmetic standard was about 4.5–6.5. The standard viscosity value of all formulations was between 2000–4000 cps. The stability test of gel preparations shows no changes in the form of low temperature storage (4º C), room temperature and high temperature (40 º C). Thereby, it can be inferred that the durian skin extract can be made in a gel preparation. This Gel has a weak antibacterial activity against Candida albicans and has no antibacterial activity against Trichophyton mentagrophytes.

 

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