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IJSTR >> Volume 1 - Issue 5, June 2012 Edition



International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616



Visible Spectrophotometric Analysis of Almotriptan Malate In Bulk And Formulations

[Full Text]

 

AUTHOR(S)

U. Viplava Prasad, M. Syam Bab, B. Kalyana Ramu

 

KEYWORDS

Almotriptan, Analysis, ACD, Beer’s Law, HA, SNP, Tablets

 

ABSTRACT

Two simple and sensitive visible spectrophotometric methods are described for the determination of almotriptan malate in bulk and pharmaceutical preparations based on the formation of colored molecular complex with sodium nitroprusside in presence of hydroxyl amine under alkaline conditions (M1) or SNP-acetaldehyde reagent (M2) and exhibiting λ max at 720 nm or 550nm respectively. The Regression analysis of Beer's Law plot showed good correlation in a general concentration range of 8-40g/ml or 4.0-20g/ml with correlation coefficient (r= 0.998) for methods M1 and M2 respectively. The proposed methods are validated with respect to accuracy, precision, linearity and limit of detection. The suggested procedures are successfully applied to the determination of the drug in pharmaceutical preparation, with high percentage of recovery, good accuracy and precision. The results of analysis have been validated statistically by repeatability and recovery studies. The results are found satisfactory and reproducible. These methods are applied successfully for the estimation of almotriptan in tablet form without the interference of excipients.

 

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