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IJSTR >> Volume 2- Issue 6, June 2013 Edition



International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616



Use Of Fusion Method For Condensation Of Sugar And Heterocyclics Basis Using Natural Phosphat As Inorganic Catalyst

[Full Text]

 

AUTHOR(S)

Driss Ouzebla, Hassan B. Lazrek, Michael Smietana, Jean-Jacques Vasseur

 

KEYWORDS

Index Terms: Natural phosphate doped with potassium iodide NP/KI, Sugar, Heterocyclic basis,β-(D,L)-Ribonucleosides and fusion method.

 

ABSTRACT

Abstract: Several D, L -ribonucleosides are prepared from 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranoside and trimethylsilylated nucleobases under mild conditions by fusion method using natural phosphate doped with KI (NP/KI) as catalyst

 

REFERENCES

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[2]. Jeannot .F, Gosselin ,Standring .G.D ,Bryant .M , Sommadossi .J.P, Loi .A.G ,La Colla .P , Mathe .C , Bioorganic & Medicinal Chemistry 2002, 10, 31533161

[3]. Clark, J. H.; Solid acids for green chemistry. Acc. Chem. Res. 2002, 35, 791-797.

[4]. Sen, S. E.; Smith, S. M.; Sullivan, K. A. Tetrahedron.1999, 55, 12657-12698 and references cited therein.

[5]. Natural phosphate (NP) comes from an ore extracted in the region of Khouribga (it is available in raw form or treated form from CERPHOS Casablanca, Morocco).

[6]. (a) Sebti, S.; Zahouily, M.; Lazrek, H.B.; Mayoral, J.A.; Macquerrie, D.J. Current Organic Chemistry 2008, 12, 203-232. (b) Lazrek . H.B, Baddi .L, Ouzebla .D, Smietana .M, Vasseur.J.J , Nucleic Acids Symposium 2008 ,52, 549550 (c) Lazrek, H.B.; Ouzebla, D.;Vasseur, J.J, Nucleosides, Nucleotides, Nucleic Acids 2007, 26, 1095-1098, (d). Zahouily, M.; Mezdar, A.; Elmakssoudi, A.; Mounir, B.; Rayadh, A.; Sebti, S.; Lazrek, H. B. ARKIVOC 2006, 31-40. (e) Zahouily, M.; Elmakssoudi, A.; Mezdar, A.; Bahlaouan, B.; Rayadha, A.; Sebti, S.; Lazrek, H. B.Lett.Org.Chem.2005,2,136138(f)Zahouily,M;Mezdar,A.;Rakik,J.;Elmakssoudi, A.; Rayadh,A.; Sebti, S. J. Mol. Catal. A: Chemical 2005, 233, 43-47

[7]. Gershonov.E, Katz .E, Karton .Y, Zafrani.Y, Tetrahedron 2007, 63, 37623767

[8]. (a) Sebti, S.; Zahouily, M.; Lazrek, H.B.; Mayoral, J.A.; Macquerrie, D.J. Current Organic Chemistry 2008, 12, 203-232. (b)Zahouily, M.; Elmakssoudi, A.; Mezdar, A.; Bahlaouan, B.; Rayadha, A.; Sebti, S.; Lazrek, H. B. Lett. Org. Chem. 2005, 2, 136-138. (c) Zahouily, M.; Mezdar, A.; Elmakssoudi, A.; Mounir, B.; Rayadh, A.; Sebti, S.; Lazrek, H. B. ARKIVOC 2006, 31-40. (d) Zahouily, M.; Bahlaouan, B.; Rayadha, A.; Sebti, S. . Tetrahedron Lett. 2004, 45, 4135-4138. (e) Alahiane, A.; Rochdi, A.; Taourirte, M.; Redwane, N.; Sebti, S.; Engels, J. W. ; Lazrek, H. B. Nucl. Nucl. & Nucleic Acids. 2003, 22,109-114. (f) Sebti, S.; Smahi, A.; Solhy, A. Tetrahedron Lett. 2002, 43, 1813-1815. (g) Zahouily, M; Mezdar, A.; Rakik, J.; Elmakssoudi, A.; Rayadh, A.; Sebti, S. J. Mol. Catal. A: Chemical 2005, 233, 43-47

[9]. Natural phosphate (NP) comes from an ore extracted in the region of Khouribga (it is available in raw form or treated form from CERPHOS Casablanca, Morocco). Prior to use this material requires initial treatments such as crushing and washing. For use in organic synthesis, the NP is treated by techniques involving attrition, sifting, calcinations (900oC), washing and recalcination. These treatments lead to a fraction between 100 and 400 lm, which is rich in phosphate. The structure of NP is similar to that of fluorapatite [Ca10(PO4)6F2], as shown by X-ray diffraction and chemical analysis. The surface area of NP was measured at m2 g-1 (nitrogen adsorption) and the total pore volume was 0.005 cm3 g-1.

[10]. Lazrek, H.B. ; Rochdi, A. ; Redwane, N.; Ouzebla, D. ; Vasseur, J.J.Letters in Organic Chemistry, 2006, 3,(4), 313-314.

[11]. Lazrek, H.B.; Ouzebla, D.;Vasseur, J.J.Nucleosides, Nucleotides, Nucleic Acids 2007, 26, 1095-1098