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IJSTR >> Volume 3- Issue 6, June 2014 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616

Allele Frequency Of P53 Gene Arg72Pro In Sudanese Meningioma Patients And Controls

[Full Text]



Alsadig Gassoum, Mohamed A.Arbab, Sawsan A. H. Aldeaf, Lamya A. Elhassan, Elshibli Elshibli, Ahmed M. Elhassan,



Key words: meningioma, P53 gene,



Abstract: The Meningiomas are one of the commonest intracranial tumors and account for 20% of all primary intracranial neoplasms. However, the true incidence is likely to be much higher, since many benign meningiomas do not produce symptoms. In autopsy studies, 2.3% of individuals harbored undiagnosed asymptomatic meningiomas, suggesting that such tumors are up to 1000 times more common than their clinically detected counterparts. Material and Method: This is a cross-sectional study that had been performed at the National Center for Neurological Sciences during February 2011 to December 2013. Result: Molecular screening of the 180 meningioma specimens, showed that the most common allele of p53 gene codon 72, in meningioma , was the arginine variant (Arg/arg), in 157 (87.2%) of the cases.



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