IJSTR

International Journal of Scientific & Technology Research

Home About Us Scope Editorial Board Blog/Latest News Contact Us
0.2
2019CiteScore
 
10th percentile
Powered by  Scopus
Scopus coverage:
Nov 2018 to May 2020

CALL FOR PAPERS
AUTHORS
DOWNLOADS
CONTACT

IJSTR >> Volume 6 - Issue 6, June 2017 Edition



International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616



Hepatoprotective Effect Of Crude Aqueous Leaf Extract Of Fig Tree, Ficus Benjamina, On Ethanol-Induced Liver Damage In Mice

[Full Text]

 

AUTHOR(S)

Aimee Lynne Pilapil, Normilando Luscano, Raizel Marie Luciano, Jeffrey Lumbres, Patricia Jin Maclan, Ivy Marie Managuelod, Erin Keshia Manlutac, Paolo Luis Paredes, Joana Punongbayan, Lailanie Jane Santiago, Pauline Dominique Sevilla, Beverly Joanne Tusca

 

KEYWORDS

Ethanol-induced hepatotoxicity, Ficus benjamina, Mice

 

ABSTRACT

Alcoholic abuse remains to be the most common cause of liver cirrhosis with significant morbidity and mortality worldwide. Herbal supplements are being used to prevent damage in excessive alcohol intake and including hepatitis from other causes as hepatoprotective agents. Fig tree is currently being utilized in studies as a potential candidate for hepatoprotection but with limited success. This study determined the hepatoprotective effect of crude aqueous leaf extract of fig tree, Ficus benjamina, on ethanol-induced hepatotoxicity in mice. In this study, fifteen Balb/c mice were assigned to negative control, positive control and treatment groups which received distilled water, Silymarin, and F. benjamina crude aqueous leaf extract respectively on day 0 to day 14. Ethanol-induced hepatotoxicity was done on day 7 to day 14 using ethanol given by oral gavage. Assessment of liver function and histology was done with the use of alanine aminotransferase (ALT) assay and histopathological study respectively. Results showed significant reduction of ALT levels in the treatment (52.40 U/L) and the positive control groups (42.58 U/L) as compared with the negative control group with a mean of 196.88 U/L (P<0.05). The difference between the positive and treatment groups was not significant (P>0.05). The degree of hepatic injury was significantly severe in the negative control group than with the treatment and positive control groups (P<0.05). On the other hand, the degree of hepatic injury showed no significant difference between the positive and treatment groups (P>0.05). Thus, the crude aqueous leaf extract of F. benjamina has hepatoprotective property on ethanol-induced hepatotoxicity in mice, similar to Silymarin. F. benjamina, as an ornamental plant, may be a source of phytochemical with potential pharmaceutical and functional activities.

 

REFERENCES

[1] Robbins & Cotran. 2010. Pathologic Basis of Disease. 8th Edition. Saunders Elsevier Inc., PA, USA. p. 867-870.

[2] Presser, A. 2000. Pharmacist's Guide to Medicinal Herbs. Smart Publications: California. p. 259-260.

[3] Terry, S. 2010. The Effect of Herbal Supplements on the Liver. Retrieved from http://www.livestrong.com/article/183567-the-effect-of-herbal-supplements-on-the-liver/.

[4] Kaur, A. J., A.K. Wahi, B. Kumar, A. Bhandari, & N. Prasad. 2011. Milk Thistle (Silybum marianum): A Review. International Journal of Pharma, Research & Development. 2(3): 1-10.

[5] Aghel, N., H. Kalantari, & S. Rezazadeh. 2011. Hepatoprotective effect of ficus carica leaf extract on mice intoxicated with carbon tetrachloride. Iranian Journal of Pharmaceutical Research, 10(1): 63-68.

[6] Mohan, K. G., E. Pallavi, R.B. Kumar, M. Ramesh, & S. Venkatesh. 2007. Hepatoprotective activity of Ficus carica Linn. leaf extract against carbon tetrachloride-induced hepatotoxicity in rats. DARU. 15(3): 162-166.

[7] Kumar, K.S. & K.L.S. Kumar. 2012. Hepatoprotective Effects of 50% Ethanolic Extract of Ficus hispida Linn Against CCl4 Induced Hepatotoxicity in Rats. European Journal of Biological Sciences, 4(1): 01-04.

[8] Kanaujia, V. K., R. Irchhaiya, H.K. Singh, D. Kailasiya, M. Verma, R.D. Yadav, & D. Shivhare. (2011). Evaluation of hepatoprotective activity on the leaves of Ficus benjamina Linn. J. Nat. Prod. Plant Resour. 1(3): 59-69.

[9] Mousa, O., P. Vuorela, J. Kiviranta, S.A. Wahab, R. Hiltohen, & H. Vuorela. 1994. Bioactivity of certain Egyptian Ficus species. J. Ethnopharmacol, 41: 71-76.

[10] Stuart S, Jones D, Day CP. 2001. Alcoholic Liver Disease: New Insights into Mechanisms and Preventive Strategies. Trends Mol Med, 7(9): 408-413.

[11] Zhou Z, Wang L, Song Z, et. al. 2003. A Critical Involvement of Oxidative Stress in Acute Alcohol-induced Hepatic TNF-α Production. Am J Pathol, 163(3): 1137-1146.

[12] Sirisha, N., M. Sreenivasulu, K.Sangeeta, C.Madhusudhana. 2010. Antioxidant Properties of Ficus Species–A Review. International Journal of Pharm Tech Research, 2(4): 2174-2182.

[13] Alvarez, V.P., R.A. Bobadilla & Muriel P. 2001. Structure-hepatoprotective Activity Relationship of 3,4-Dihydrocyanic. Journal of Applied Toxicology, 2: 257-351.

[14] Domitrovic, R., H. Jakovac, V.V. Marchesi, K.S. Vladimir, O. Cvijanovic, A. Tadic, E. Romic, & D. Rahelic. 2012. Differential hepatoprotective mechanisms of rutin and quercetin in CCl4-intoxicated BALB/cN mice. Acta Pharmacologica Sinica, 33(1): 1260.

[15] Jayaraman, J., V.A. Jesudoss, V.P. Menon, & N. Namasivayam. 2012. Anti-inflammatory role of naringenin in rats with ethanol induced liver injury. Toxicol Mech Methods 22(7): 568-576.