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International Journal of Scientific & Technology Research

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IJSTR >> Volume 10 - Issue 7, July 2021 Edition



International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616



SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF NEW THIOHYDANTOIN SCHIFF BASE COMPLEXES

[Full Text]

 

AUTHOR(S)

N.A.Farouk,, Ahmed.R.E.Mahdy, El-Sherbiny H. EL-Sayed

 

KEYWORDS

Thiohydantoin, Spectroscopic study, SEM, XRD, Cytotoxicity.

 

ABSTRACT

A novel thiohydantoin Schiff base (THSB) ligand and its complexes {M(II)THSB; M = Mn(II), Cu(II), Zn(II)} have been succefully synthesized. This series of Mn(II), Cu(II) and Zn(II) complexes of novel thiohydantoin Schiff base ligand (THSB, HL) have been prepared by reaction of ligand with metal(II) chlorides in 1:1 molar ratio. The coordination profiles of HL with M(II) ions, stoichiometry, and stereochemistry of metal complexes were investigated based upon various physicochemical and spectroscopic techniques. The thermal stability and surface morphological features of the free ligand and its coordination compounds have been studied using TGA, DTA, SEM and XRD analysis. The comparative in-vitro anticancer studies revealed cytotoxicty of the parent ligands and its complexes against MCF-7, and the result showed that Cu(II)THSB complex was the most potent compounds against MCF-7 with IC50 value of 2.62 mg/mL. That may offering a probable alternative to conventional chemotherapeutic agents for cancer therapy. The comparative in-vitro anticancer studies revealed cytotoxicty of the parent ligands and its complexes against MCF-7, and the result showed that Cu(II)THSB complex was the most potent compounds against MCF-7 with IC50 value of 2.62 mg/mL. That may offering a probable alternative to conventional chemotherapeutic agents for cancer therapy.

 

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