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Effective Synergetic Catalytic System For The Efficient Synthesis Of Multicomponent Biginelli-Type Pyrimidinone Derivatives
[Full Text]
AUTHOR(S)
Hari R. Pawar, Narendra R. Kamble, Vinod T. Kamble
KEYWORDS
Multicomponent reaction, Niobium pentachloride, Cyclopentanone, Aryl aldehyde, Pyrimidinone
ABSTRACT
A simple, clean and efficient Biginelli-type reaction was reported towards single-pot synthesis of pyrimidinone derivatives using cyclopentanone, aryl aldehyde and urea/thiourea. In this transformation niobium pentachloride acts as excellent catalyst in presence of silver salt. Under identical experimental conditions, thiourea exhibited similar behavior as compared to urea.
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