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IJSTR >> Volume 8 - Issue 8, August 2019 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616

Effective Synergetic Catalytic System For The Efficient Synthesis Of Multicomponent Biginelli-Type Pyrimidinone Derivatives

[Full Text]



Hari R. Pawar, Narendra R. Kamble, Vinod T. Kamble



Multicomponent reaction, Niobium pentachloride, Cyclopentanone, Aryl aldehyde, Pyrimidinone



A simple, clean and efficient Biginelli-type reaction was reported towards single-pot synthesis of pyrimidinone derivatives using cyclopentanone, aryl aldehyde and urea/thiourea. In this transformation niobium pentachloride acts as excellent catalyst in presence of silver salt. Under identical experimental conditions, thiourea exhibited similar behavior as compared to urea.



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