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Effect Of Pinealectomy And Recovery Treatment Of Melatonin Dose On Vertebral Column Of Catfish (Heteropneustes Fossilis)
[Full Text]
AUTHOR(S)
Reeti Panchal, Sudesh Rani
KEYWORDS
catfish, melatonin, minerals contents, pineal removal, vertebral column
ABSTRACT
In order to study the effects of pineal removal on catfish (Heteropneustes fossilis) vertebral column, three groups of catfishes were formed.) Group-A was taken as control where normal fishes were placed. In Group-B, the surgery of pineal gland was performed i.e. pineal gland was removed and considered as pinealectomized group. Group-C fishes were pinealectominzed, administered with injections of 200mg melatonin dose/Fish. At the end of experimental period, growth abnormality in vertebral column and minerals contents in bones were measured. Results indicate that in pinealectomized group and melatonin received group fishes, the growth was reduced and hence lives weight gain values were obtained with negative sign. Results on vertebral column suggested that more curvature in spine was recorded in pinealectominzed fish. Whereas the fish which received melatonin dose the change in vertebral column was only slightly. Which indicates that melatonin is helpful to overcome the deficiency of mineral contents in bone.
REFERENCES
[1] Amstrup, A.K., Sikjaer, T., Heickendorff. L., Mosekilde. L., & Rejnmark, L. (2015). Melatonin improves bone mineral density at the femoral neck in postmenopausal women with osteopenia: a randomized controlled trial. J Pineal Res. Sep;59(2):221-9.
[2] Amstrup, A.K., Sikjaer, T., Mosekilde, L. & Rejnmark, L. (2013). Melatonin and the skeleton Osteoporos Int. Dec;24(12):2919-27.
[3] Bao, T., Zeng, L., Yang, K., Li, Y., Ren, F., Zhang, Y. & Gao, Z. (2019). Can Melatonin Improve the Osteopenia of Perimenopausal and Postmenopausal Women? A Meta-Analysis. Int J Endocrinol. 2019 Apr 7;2019: 51516-78.
[4] Beuerlein, M., Wang, X., Moreau, M., Raso, J., Mahood, J., & Bagnall, K. (2001). Development of scoliosis following pinealectomy in young chickens is not the result of an artifact of the surgical procedure. Microscopy research and technique, 53(1), 81-86.
[5] Beuerlein, M., Wilson, J., Moreau, M., Raso, V. J., Mahood, J., Wang, X., & Bagnall, K. M. (2001). The critical stage of pinealectomy surgery after which scoliosis is produced in young chickens. Spine, 26(3), 237-240.
[6] Cardinali, D. P., Ladizesky, M. G., Boggio, V., Cutrera, R. A., & Mautalen, C. (2003). Melatonin effects on bone: experimental facts and clinical perspectives. Journal of pineal research, 34(2), 81-87.
[7] Chin, H.N., Loh, R., Hong, Y.C. & Gibson-Kueh, S. (2016). Case studies of spinal deformities in ornamental koi, Cyprinus carpio L. Journal of Fish Diseases, 40(1):65-71
[8] De Vlaming, V. (1980). Effects of pinealectomy and melatonin treatment on growth in the goldfish, Carassius auratus. General and comparative endocrinology, 40(2), 245-250.
[9] Fischer, T.W., Slominski, A., Tobin, D.J. & Paus, R. (2008). Melatonin and the hair follicle. Journal of Pineal Research. ;44(1):1–15.
[10] Fjelldal, P.G., Grotmol, S. & Kryvi, H. (2004). Pinealectomy induces malformation of the spine and reduces the mechanical strength of the vertebrae in Atlantic salmon, Salmo salar. Journal of Pineal Research. ;36(2):132–139.
[11] Francis, T., Ramanathan, N., & Padmavathy, P. (2004). Role of the pineal organ and melatonin in fish. World aquaculture. 21-69.
[12] Ghosh, J., & Nath, P. (2005). Seasonal effects of melatonin on ovary and plasma gonadotropin and vitellogenin levels in intact and pinealectomized catfish, Clarias batrahus (Linn). Indian Journal of Experimental Biology, 43, 224-232.
[13] Gitto, E., Pellegrino, S., Gitto, P., Barberi, I. & Reiter, R.J. (2009). Oxidative stress of the newborn in the pre- and postnatal period and the clinical utility of melatonin. Journal of Pineal Research. ;46(2):128–139.
[14] Hakanson, D. O., & Bergstrom, W. H. (1981). Phototherapy-induced hypocalcemia in newborn rats: prevention by melatonin. Science, 214(4522), 807-809.
[15] Inoh, H., Kawakami, N., Matsuyama, Y., Aoki, T., Kanemura, T., Natsume, N., & Iwata, H. (2001). Correlation between the age of pinealectomy and the development of scoliosis in chickens. Spine, 26(9), 1014-1021.
[16] Jan, J.E., Reiter, R.J., Wasdell, M.B.& Bax, M. The role of the thalamus in sleep, pineal melatonin production, and circadian rhythm sleep disorders. Journal of Pineal Research. 2009;46(1):1–7.
[17] Karsenty, G. and Oury, F. (2012). Biology Without Walls: The Novel Endocrinology of Bone Annual Review of Physiology Vol. 74:87-105
[18] Karsenty G, Ferron M (2012) The contribution of bone to whole-organism physiology. Nature 481:314–320
[19] Koyama, H., Nakade, O., Takada, Y., Kaku, T., & Lau, K. H. W. (2002). Melatonin at pharmacologic doses increases bone mass by suppressing resorption through down‐regulation of the RANKL‐mediated osteoclast formation and activation. Journal of Bone and Mineral Research, 17(7), 1219-1229.
[20] Kristen, F. Gorman & Felix B. (2007). Review Teleosts as models for human vertebral stability and deformity. Comparative Biochemistry and Physiology, Part C 145 28–38
[21] Machida, M., Dubousset, J., Satoh, T., Murai, I., Wood, K. B., Yamada, T., & Ryu, J. (2001). Pathologic mechanism of experimental scoliosis in pinealectomized chickens. Spine, 26(17), 385-391.
[22] Maldonado, M.D., Murillo-Cabezas, F. & Terron, M.P. (2007). The potential of melatonin in reducing morbidity-mortality after craniocerebral trauma. Journal of Pineal Research. ;42(1):1–11.
[23] Man, G. C. W., Wang W. W. J., Yim A. P. Y., Wong J. H.,Ng T. B., Lam T. P.,Lee S. K. M., Ng B. K. W., Wang C. C., Qiu Y. & Cheng J. C. Y.. (2014). A Review of Pinealectomy-Induced Melatonin-Deficient Animal Models for the Study of Etiopathogenesis of Adolescent Idiopathic ScoliosisInt J Mol Sci. 2014 Sep; 15(9): 16484–16499.
[24] Paul, E. W. Owen, M. A. G., Ramon, F. & Mieke, S. (2015). A primary phosphorus-deficient skeletal phenotype in juvenile Atlantic salmon Salmo salar: The uncoupling of bone formation and mineralization. Journal of Fish Biology 88(2) pp1-19
[25] Peschke, E. (2008). Melatonin, endocrine pancreas and diabetes. Journal of Pineal Research. ;44(1):26–40.
[26] Shah, K. V., Kapupara, P. K., & Desai, T. R. (2011). Determination of sodium, potassium, calcium and lithium in a wheat grass by flame photometry. Pharma Science Monitor An International Journal of Pharmaceutical Sciences, 900-909.
[27] Turgut, M., Kaplan, S., Turgut, A. T., Aslan, H., Güvenç, T., Çullu, E., & Erdoǧan, S. (2005). Morphological, stereological and radiological changes in pinealectomized chicken cervical vertebrae. Journal of pineal research, 39(4), 392-399.
[28] Witt-Enderby, P.A., Radio, N.M., Doctor, J.S. & Davis, V.L. (2006). Therapeutic treatments potentially mediated by melatonin receptors: potential clinical uses in the prevention of osteoporosis, cancer and as an adjuvant therapy. Journal of Pineal Research. 2006;41(4):297–305.
[29] Zhou, W., Liu, Y., Shen, J., Yu, B., Bai, J., Lin, J., Guo. X., Sun, H., Chen, Z., Yang, H., Xu, Y. & Geng, D. (2019). Melatonin Increases Bone Mass around the Prostheses of OVX Rats by Ameliorating Mitochondrial Oxidative Stress via the SIRT3/SOD2 Signaling Pathway. Oxid Med Cell Longev. 2019 Apr 11; 4019619.
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