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IJSTR >> Volume 8 - Issue 8, August 2019 Edition



International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616



Tandem Synthesis And Antibacterial Studies Of Novel 3-Substituted Tetrahydrobenzo [4,5] Thieno [1,2,4] Triazolo [4,3-B] Pyridazine And 2- (5- (Substituted) -4h-1,2,4-Triazole-3-Yl) -Tetrahydrobenzo [B] Thiophene-3-Carbonitirile Derivatives

[Full Text]

 

AUTHOR(S)

N. Devika, J. Sembian Ruso, M. Mariyappan, N. Sivakumar

 

KEYWORDS

1,2,4-triazolopyridazine, 6,7,8,9-tetrahydrobenzothienopyridazine, Boronic acid, and Antibacterial activity.

 

ABSTRACT

A series of novel 3-substituted tetrahydrobenzo [4,5] thieno [1,2,4] triazolo [4,3-b] pyridazine and 2- (5- (substituted) -4H-1,2,4-triazole-3-yl) -4,5,6,7-tetrahydrobenzo [b] thiophene-3-carbonitrile derivative were synthesized. The structures of all derivatives were characterized by LCMS, 1H NMR 13C NMR spectroscopy. Newly synthesized compounds (8a-8f) and (9a-9h) were subjected for their invitro antibacterial screening against Bacillus substilis, Staphylococcus aureus, Klebsiella pneumonia, Escherichia coli R. solanacearum Among the tested compounds, compounds 7d, 7f and 8f exhibited significant antibacterial activity.

 

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