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IJSTR >> Volume 6 - Issue 5, May 2017 Edition



International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616



Effects Of Both Ethanol And Water Extracts Of Buccholzia Coriacea On Sodium Arsenite Induced Liver Damage In Male Albino Rats.

[Full Text]

 

AUTHOR(S)

Fakoya A.

 

KEYWORDS

Alcoholic, Hepatoprotective, Hepatotoxicity Mutagenic,,.

 

ABSTRACT

The hepatoprotective effects of two extracts (alcoholic extract and water extract ) obtained from the air dried seeds of Buccholzia coriacea were investigated. Sodium arsenite is shown to elicit strong mutagenic activity and hepatotoxicity. This work therefore seeks to induce liver damage in rats using a single dose (10 mg/kg i.p) of sodium arsenite and to evaluate the possible protective effects of oral administration of different doses of 100, 200, 300, and 400mg/kg of both water and alcoholic extracts of Buccholzia coriacea seeds on sodium arsenite induced liver damage. Rats were pretreated with 100, 200, 300, and 400mg/kg of the extracts for five days before a single dose of Na2AsO3 (10mg/kg) on the sixth day. The alanine aminotranferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) activities were determined in serum and tissue of rats. Sodium arsenite caused liver damage as evident by statistically significant (p < 0.05) increased in serum and tissue activities of ALT, AST, ALP and LDH. However, all the tested plant extracts elicited counter effect at dose dependent manner. The present results suggest that Buccholzia coriacea can act as hepatoprotective against liver damage.

 

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