International Journal of Scientific & Technology Research

IJSTR@Facebook IJSTR@Twitter IJSTR@Linkedin
Home About Us Scope Editorial Board Blog/Latest News Contact Us

IJSTR >> Volume 6 - Issue 5, May 2017 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616

Effects Of Both Ethanol And Water Extracts Of Buccholzia Coriacea On Sodium Arsenite Induced Liver Damage In Male Albino Rats.

[Full Text]



Fakoya A.



Alcoholic, Hepatoprotective, Hepatotoxicity Mutagenic,,.



The hepatoprotective effects of two extracts (alcoholic extract and water extract ) obtained from the air dried seeds of Buccholzia coriacea were investigated. Sodium arsenite is shown to elicit strong mutagenic activity and hepatotoxicity. This work therefore seeks to induce liver damage in rats using a single dose (10 mg/kg i.p) of sodium arsenite and to evaluate the possible protective effects of oral administration of different doses of 100, 200, 300, and 400mg/kg of both water and alcoholic extracts of Buccholzia coriacea seeds on sodium arsenite induced liver damage. Rats were pretreated with 100, 200, 300, and 400mg/kg of the extracts for five days before a single dose of Na2AsO3 (10mg/kg) on the sixth day. The alanine aminotranferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) activities were determined in serum and tissue of rats. Sodium arsenite caused liver damage as evident by statistically significant (p < 0.05) increased in serum and tissue activities of ALT, AST, ALP and LDH. However, all the tested plant extracts elicited counter effect at dose dependent manner. The present results suggest that Buccholzia coriacea can act as hepatoprotective against liver damage.



[1]. Goldsmith MA, Slavik M and Carter SK. Quantitative prediction of drug toxicity in humans from toxicology in small and large animals. Cancer Res. 1975, 35: 1354- 1364.

[2]. Begg CB and Carbone PP. Clinical trials and drug toxicity in the elderly. The experience of the Eastern Cooperative Oncology Group. Cancer. 1983, 52: 1986-1992.

[3]. Akter KF, Owens G, Davey DE, and Naidu, R. Rev Environ.Contam. Toxicol. , 2005, 184: 97–149.

[4]. Rahman MM, Sengupta MK, Ahamed S, Chowdhury UK, Lodh D, Hossain A et al. Bull World Health Organ. 2005, 83: 49–57.

[5]. Hei TK, Liu SX and Waldren. Proc. Natl. Acad. Sci., USA. 1998, 95: 8103 –8107.

[6]. Shila S, Kokilavani V, Subathra M, Panneerselvam C. Toxicology . 2005, 210: 25–36.

[7]. Valko M, Morris H, and Cronin MT. Curr. Med. Chem. 2005, 12: 1161–1208.

[8]. Akpayung EO, Udoh AP and Akpan EJ. Chemical composition of the edible leaves of Pterocarpus mildbreadii. Plant Foods Hum. Nutr., 1995, 43(3):209.

[9]. Awouters F, Niemegears CJE, Lenearts FM and Janssen PAJ. Delay of castor oil diarrhea in rats: a new way to evaluate inhibitors of prostaglandin biosynthesis. J. Pharm. Pharmacol., 1978, 30: 41-45.

[10]. Culpeper Nicholas Culpeper’s. Complete Herbal: A Book of Remedies of Ancient Ills. (The Word’s Worth Reference Collection Library) Contemporary Publishing Company. 1995.

[11]. Grieve Maud. A Modern Herbal.Harmonds Worth. England: Penguin Books. 1984, (First published in 1931).

[12]. Ibrahim TA and Fagbonun ED. Antibacterial and Antifungal Activity of Ethanolic and Methanolic Extracts of Dried Seeds of Buchhlozia coriacea. Greener Journal of Agricultural Science. 2013b, 3 (6): 458-463.

[13]. Fred-Jaiyesimi OO, Anthony O and Egebunmi O. Larvicidial effect of pet ether,chloroform fractions and methanol extract of Buccholzia coriacea Engle seed. International Journal of Pharmaceutical Science and Research. 2011, 2(7): 1736-1738.

[14]. Azuzu IU. Pharmalogical evaluation of folklores of Sphenostylia slenocarpa. J. Ehnophamacol., 1986, 16: 236-267.

[15]. Reitman S and Frankel S. A colorimetric method for the determination of serum GOT and GPT. American Journal of Clinical Pathology. 1975, 28:57- 60.

[16]. Block G, Patterson B and Subar A. Fruit, Vegetable and Cancer prevention a review of the epidemiological evidence. Nutr.Cancer. 1992, 18: 1-29.

[17]. Hertog MG and Faskens EJM. Dietary antioxidant flavonoids and risk of coronary heart diseases. The Zulphens Elderly study. Lancet. 1993, 342: 1007-1011.

[18]. Tseng TH, Hsu JD and Lo MH. Inhibiting effect of Hibiscus protocatechuic acid on tumor promotion in mouse skin. Cancer letters. 1998, 126(2):199-207.

[19]. Farrel GC. Drug induced liver disease. Edinburgh Churchill living stone. 1994.

[20]. Vermeulen NPE, Bessems JGM, and Vande straat R. Molecular aspect of paracetamol induced hepatotoxicity and its mechanism-based preventions. Drug Metab. Rev. 1992, 24: 367-407.