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IJSTR >> Volume 6 - Issue 9, September 2017 Edition



International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616



Optimization Of Rheological Properties In The Formulation Of An Ointment Base From Natural Ingredients

[Full Text]

 

AUTHOR(S)

R. K. Tsatsop, G. Djiobie, K. Regonne, V. Bama, A. Mbawala, M. Ngassoum

 

KEYWORDS

Formulation, hard thickeners, ointment base, rheological properties.

 

ABSTRACT

The purpose of this study was to optimize the formulation of ointment base by using statistical mixture design. Screening of hard thickeners (Palm Stearin, Beef Tallow and Beeswax) was done to choose the best hard thickener or combination of hard thickeners whose nature and proportions would give the best semi-solid and consistent ointment with desired rheological properties (Spreadability, viscosity, hardness). Contour plots of each response were depicted, based on the equation given by the statistical-fitted models. The optimum area for the ointment base properties, were located and the combination Beeswax:Palm stearin:Beef Tallow was chosen. Other optimization was done to check the contribution of different factors (Hard Thickener, Soft Thickener and Lubricant) on the rheological properties and their correlation. A strong inverse correlation was found to exist between the spreadability and the viscosity of the ointment base (91%). A multi-response optimization was done to obtain a combined optimum proportion of ingredients that gave us 5% HT, 84%ST and 11% L. It can be concluded that the ointment base obtained with optimal rheological and drug release properties can be used for cosmetic and pharmacological applications. The plant extracts can be incorporated in this matrix for herbal ointments.

 

REFERENCES

[1] I.Biljana , T. Loftsson, M. A. Hjalmarsdottir and G. M. Asgrimsdottir, Topical Formulation Comprising Fatty Acid Extract from Cod Liver Oil: Development, Evaluation and Stability Studies. Mar. Drugs. 14 (2016) 105-116
[2] Tamburic, A Comparison of Electrical and Rheological Techniques for the Characterization of Creams. Int. J. Pharm., 137 (1996) 243–248
[3] B.W. Barry and A.J. Grace, Sensory Testing of Spreadability: Investigation of Rheological Conditions Operative During Application of Topical Preparations. J Pharm Sci, 61 (1972) 335–341.
[4] D.S. Jones, A.D. Woolfson, and A.F. Brown, Texture, Viscoelastic, and Mucoadhesive Properties of Pharmaceutical Gels Composed of Cellulose Polymers. International Journal of Pharmaceutics, 151 (1997) 223–233.
[5] S.P. Chaudhari, P.S. Patil, Pharmaceutical Excipients: A review. Int. J. Adv. Pharm. Biol. Chem. 1 (2012) 21–34.
[6] R.K. Chang, A. Raw, R. Lionberger and L. Yu, Generic development of topical dermatologic products: Formulation development, process development, and testing of topical dermatologic products. AAPS J, 15 (2013) 41–52.
[7] L. B. Karam, C. Ferrero, M. N. Martino, N. E. Zaritzky and M. V. Grossman, Thermal, microstructural and textural characterization of gelatinized corn, cassava and yam starch blends. Int. J. Food Sci. Tech, 41(2006) 805 – 812.
[8] C. A. Alalor, I. I. Cecilia, P. A. Chukwuemeka, Evaluation of the Antibacterial activity of Herbal ointments formulated with Methanolic extract of Cassia alata. Asian Journal of Biomedical and pharmaceutical Sciences. 2 (2012) 15-19.
[9] Prabhudutta Panda, Formulation and evaluation of topical dosage form of Alangium salvifolium linn. and their wound healing activity. Asian Journal of Pharmaceutical Sciences and research. 1 (2011) 10-22.
[10] D. Akanksha, G. Vikas, K. J. Neetesh, S. Shalendra, B. Neelam, K. J. Dinesh Formulation and Evaluation of Neomycin Sulphate Ointment containing Natural Wound Healing Agent Curcuma longa, International Journal of Pharmaceutical Sciences and Drug Research. 1 (2009) 105–118.
[11] V. L. Singleton, J. A. Rossi Jr, Colorimetry of total phenolics with phosphomolybdic–phosphotungstic acid reagents, Am. J. Enol.Vitic.16 (1965) 144–158.
[12] M. Koushki,, M. Nahidi and F. Cheraghali, Physico-chemical properties, fatty acid profile and nutrition in palm oil. Journal of Paramedical Sciences (JPS) 6 (2015) 117 -134
[13] H. Sharma, R. Giriprasad and M. Goswami, Animal fat-Processing and Its Quality Control. J Food Process Technol J Food Process Technology 4 (2013) 4-8
[14] Stefan Bogdanov. Quality and standard of Pollen and beewax. APIACTA 38 ((2004) 333-341
[15] T.H. Shellhammer, T.R. Rumsey, J.M. Krochta, Viscoelastic properties of edible lipids. J. Food Eng. 33 (1997) 305–320.
[16] S. Amit, B. Saraswati, U. Kamalesh, U. Kumud, Formulation and Evaluation of a Novel Herbal Gel of Equisetum arvense Extract, Journal of Pharmacognosy and Phytochemistry. 1 (2013) 80-86
[17] M. D. Lemuel and L. Tianying, Absolute Viscosities of Vegetable Oils at Different Temperatures and Shear Rate Range of 64.5 to 4835 s−1. Journal of Food Processing ID 234583 (2014) 6 pages
[18] L. S. Hwang, Semame oil, Researchgate 12 (2005) 537–572
[19] T. Hegdahl and N.R. Gjerdet, Flowing of Light-Bodied Elastic Impression Materials, Acta. Odontol. Scand. 39 (1) (1981) 33–38
[20] B. Vennat, D. Gross, and A. Pourrat, “Procyanidin Gels Based on Cellulose and Carrageenan Derivatives,” Drug Dev. Ind. Pharm. 18 (14) (1992) 1535–1548.
[21] S. Pattanayak, S. S. Nayack, S. C. Dinda, D. Panda and K.P. Naval, Evaluation of herbal ointments formulated with methanolic extract of Cajanus scarabaeides, J. Pharm. Allied health Sci. 1 (2) (2011) 47–59