IJSTR

International Journal of Scientific & Technology Research

Home About Us Scope Editorial Board Blog/Latest News Contact Us
0.2
2019CiteScore
 
10th percentile
Powered by  Scopus
Scopus coverage:
Nov 2018 to May 2020

CALL FOR PAPERS
AUTHORS
DOWNLOADS
CONTACT

IJSTR >> Volume 2- Issue 10, October 2013 Edition



International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616



"Study Of Serum C-Peptide Levels In 50 Newly Detected Diabetes Subjects Of Age Group 30-40 Years In Nellore"

[Full Text]

 

AUTHOR(S)

V.V.N.Goutham, M.V.K.Chaitanya, Kale Dasu

 

KEYWORDS

Key words: c-peptide, Diabetes, Age, BMI.

 

ABSTRACT

ABSTRACT: Background: Diabetes mellitus ,a chronic metabolic disorder, is a major cause of mortality and morbidity worldwide. Measurement of C-peptide, which is co-secreted with insulin from beta cells of pancreas (proinsulin, insulin C-peptide) provides an index of endogenous insulin Production and pancreatic beta cell function. This study is to demonstrate or test the ability of serum C-peptide levels as a marker in initiating appropriate drug therapy and classifying newly detected diabetes in subjects between the age group 30 and 40 years. Aim: To investigate the ability of classifying diabetes mellitus with serum C-peptide levels in 50 young (30-40 years) newly detected diabetic subjects. To distinguish those who require insulin treatment from others who can be managed by diet, exercise and oral anti diabetic drugs as initial therapy. Method: This is a hospital based cross-sectional study has been carried for more than one and half year in the Department of General Medicine, Narayana Medical College & Hospital, Nellore involving 50 patients. Data collection was done by clinical history, examination and investigations. These details were recorded. The data collected was subjected to statistical analysis for determining the significance of the results. Informed consent and their willingness obtained from these subjects have been documented. Results: Measurement of C-peptide levels in a young newly detected diabetic adult helps us a) to distinguish between type 1 behaviour and type 2 behaviour b) in initiation of treatment. Majority of the subjects who had low serum C-peptide levels also had low BMI, suggesting a positive correlation between C-peptide levels and BMI. Majority of the subjects with positive family history had normal or high serum C-peptide levels suggesting a positive family history favours type 2 behaviour. Conclusions: This study suggests measurement of C-peptide levels in newly detected diabetic subjects is of great value.

 

REFERENCES

[1]. American Diabetes Association: Standards of medical care in diabetes. Diabetes Care 34:S11, 2011

[2]. Sarah Wild, Gojka Roglic, Anders Greus, Richard Sierce, Hilary King. Global prevalence of diabetes. Diabetes Care 2004;27:1047-53.

[3]. Das AK, Rai M. A world without diabetes and its complications: A preventive program. In: Type 2 Diabetes and its complications: A preventive program, Jayaram BM, ed. Bangalore: Micro Labs Limited; 2008. p. 1.

[4]. Alvin C Powers. Diabetic mellitus. 17th ed. Chapter 338. In: Harrison’s Principlesof Internal Medicine, Braunwald, Fauci, Kasper, Hauser, Longo, Jameson. Loscalzo: McGraw-Hill Companies; 2008. p. 2275.

[5]. Diagnosis and classification of Diabetes mellitus. Diabetes Care 2009 Jan; 32(1):S62-S67.

[6]. King H. Global burden of diabetes 1995 to 2025. Prevalence, numerical estimates and projection. Diabetes Care 1998;21(9):1414-31.

[7]. Tripathi BK, Srivastava AK. Diabetes mellitus: Complications and therapeutics. Med Sci Monit 2006;12(7):RA131.

[8]. Zimmet P, Turner R, McCarthy D, Rowley M, Mackay I. Crucial points at diagnosis. Diabetes Care 1999;22:B59-B64.

[9]. American Diabetes Association. Clinical Practice Recommendations 2007. Diabetes Care 2007;30:S4.

[10]. Zimmet PZ, Tuomi T, Mackay IR, Rowley MJ, Knowles DW, Cohen M, Lang DA. Latent autoimmune diabetes mellitus in adults (LADA): The role of antibodies to glutamic acid decarboxylase in diagnosis and prediction of insulin dependency. Diab Med 1994;11:299-303.

[11]. Turner R, Strattor I, Horton V, et al. UKPDS 25; auto antibodies to islet cell cytoplasm and glutanic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. UK Prospective Diabetes Study Group. Lancet 1997;350:1288-93.

[12]. Horton V, Stratton I, Bottazzo GF, et al. Genetic heterogeneity of autoimmune disease: age of presentation in adults is influenced by HLA DRBI and DQBI genotypes (UKPDS43). UK Prospective Diabetes Study (UKPDS) Group. Diabetologia 1999;42:608-16.

[13]. Carlsson A, Sundkvist G, Groop L, et al. Insulin and glucagon secretion in patients with slowly progressing auto immune diabetes (LADA). J Clin Endocrinol Metab 2000;85:76-80.

[14]. David Snadderi, Robert Liangold. Hisotry taking. 11th ed. Chapter 1. in: Macleod’s Clinical examination, Graham Douglas, Fiona Nicol, Colin Roberton, eds. New York: Elsevier Churchill Livingstone; 2005. p. 17.

[15]. Zimmet P. The pathogenic and prevention of diabetes in adults: genes, autoimmunity, and demography. Diabetes Care 1995;18:1050-64.

[16]. Mary Ann Banerji, Nuzhat Faridi, Rajesh Atluri, et al. Body compositions, visceral fat, septis and insulin resistance in Asian Indian mass. J Clin Endocrinol Metab 1999;84:137-44.

[17]. Laakso M, Ronnemaa T, Sarlund H, Pyorala K, Kallio V. Factors associated with fasting and post glucagon plasma C-peptide levels in middle aged insulin- treated diabetic patients. Diabetes Care 1989 Feb;12(2):83-8.

[18]. Park SW, Ihus SH, et al. Differential effects of ambient blood glucose level and degree of obesity as basal serum C-peptide level and the C-peptide response to glucose and glucagon in NIDDM. Diabetes Res Clin Pract 1997;37(3):165-71.

[19]. Renato Pasguali, Francesco Casimissi, Stefania Cantobelli, et al. Effect of obesity and body fat distribution as sex hormones and insulin in men. Metabolism. 1991 Jan;40(1):101-4.

[20]. Chandalia M, Lin P, Sreenivasan T, et al. Insulin resistance and body fat distribution in South Asian men compared to Caucasian men. PLOSONE 2007;2(8):e812.

[21]. Gaya W Katulanda, Prasad Katulanda, Adler AI, et al. Apolipoproteins in diabetes dyslipidemia in South Asians with young adult onset diabetes; distribution, associations and patterns. Annals of Clinical Biochemistry 2010;47:29.

[22]. Hostetter TTH. Diabetic nephropathy. 4th ed. Chapter 34. In: The kidney, Brenner,Recter, eds. Philadelphia: WB Saunders Company 1991;11:1696-719.

[23]. Steiner DF, Oyer PE. The biosynthesis of insulin and a probable precursor of insulin by a human islet cell adenoma. Proceedings of the National Academy of Sciences of the United States of America 1967;57(2):473-80.