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IJSTR >> Volume 8 - Issue 11, November 2019 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616

Effect Of Manganese On Epididymal Functions And Fertility Of Wistar Male Rats

[Full Text]



Milan Chandel, G. C. Jain



Cauda epididymis,fertility, histoarchitecture, lipid peroxidation, manganese chloride, sperm count



Manganese (Mn) is a naturally occurring essential trace element which act as cofactor for many cellular enzymes. Although it is essential at low levels but the excessive exposure of the Mn has been reported to be toxic. The aim of present study was to elucidate the toxic effect of manganese chloride (MnCl2.4H2O) on sperm parameters and oxidative status of cauda epididymis and fertility of male Wistar rats. Thirty two adult, male Wistar rats were randomly divided into four groups each having eight animals. Group A served as control and received normal saline (0.5 ml/rat) as vehicle while Group B, C and D received 50, 100 and 150 mg/kg b.wt. MnCl2 per day respectively, orally, for 60 days. The results of present study showed marked decline in sperm count, motility, viability, litter size and fertility and significant rise in sperm morphological abnormalities in rats exposed with MnCl2 as compared to control rats. A significant increase in lipid peroxidation, simultaneous decrease in antioxidant defense parameters and marked degenerative and atrophic changes in cauda epididymal histoarchitecture was also noticed in MnCl2exposed rats.Thus, the findings of the present study suggested that manganese chloride exposure had significant impairment of sperm parameters, fertility, oxidative status and histoarchitecture of cauda epididymis of Wistar rats.



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