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IJSTR >> Volume 9 - Issue 1, January 2020 Edition



International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616



Features In Creating Polymer Forms Of Drugs

[Full Text]

 

AUTHOR(S)

Sarimsakov Abdushukur Abdikhalilovich, Nurgaliev Ilnar Nakipovich, Kholturaev Bakhriddin Zhumaevich

 

KEYWORDS

polymer, drug, biodegradations, cellulose, carboxymethylcellulose, nanostructured, biological activity.

 

ABSTRACT

In this article, the results of medicinal compounds polymeric forms classification and principles of their development are discussing. The basic requirements for carrier polymers and polymers with own biological activity are developed. The main differences in creating low-molecular drugs, their polymer forms and polymers with their own biological activity. Polications assigned to the group of ionenes were isolated and examined separately. Heterochain polymers containing quaternary nitrogen atoms at certain distances from each other are classified as ionenes. Ionenes have high bactericidal activity depending on the structure, which is explained by their adsorption to the bacterial cell walls. The formation of polyelectrolyte complexes with DNA is possible with the penetration of ionenes into bacteria cells. Polyanions are also referred to polymer forms of medical substances. Biological effect of exogenous polyanions is explained by competitive mechanisms rather than with the formation of polycomplexes. Weak biological activity of a number of polyanions has been established as antitumor, immunomodulatory, interferon-inducing and other activities. However, due to weak biological activity, they cannot be used in practical medicine. The scientific work also examined the molecular construction of medicinal polymers that provide prolongation, selectivity, reduced side effects, preservation of therapeutic concentration in the body, reduced toxicity and increased specific effects of the drug. Were established limitations for carrier polymers in molecular construction and creation of polymer forms of drugs. A list of classes of drugs, for which the creation of their dosage forms is relevant, was also defined. Based on the results of the research, it was concluded that drug polymers and practical possibilities of their creation are in many cases unique and cannot be achieved with the use of low molecular weight drugs.

 

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