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IJSTR >> Volume 9 - Issue 1, January 2020 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616

Features In Creating Polymer Forms Of Drugs

[Full Text]



Sarimsakov Abdushukur Abdikhalilovich, Nurgaliev Ilnar Nakipovich, Kholturaev Bakhriddin Zhumaevich



polymer, drug, biodegradations, cellulose, carboxymethylcellulose, nanostructured, biological activity.



In this article, the results of medicinal compounds polymeric forms classification and principles of their development are discussing. The basic requirements for carrier polymers and polymers with own biological activity are developed. The main differences in creating low-molecular drugs, their polymer forms and polymers with their own biological activity. Polications assigned to the group of ionenes were isolated and examined separately. Heterochain polymers containing quaternary nitrogen atoms at certain distances from each other are classified as ionenes. Ionenes have high bactericidal activity depending on the structure, which is explained by their adsorption to the bacterial cell walls. The formation of polyelectrolyte complexes with DNA is possible with the penetration of ionenes into bacteria cells. Polyanions are also referred to polymer forms of medical substances. Biological effect of exogenous polyanions is explained by competitive mechanisms rather than with the formation of polycomplexes. Weak biological activity of a number of polyanions has been established as antitumor, immunomodulatory, interferon-inducing and other activities. However, due to weak biological activity, they cannot be used in practical medicine. The scientific work also examined the molecular construction of medicinal polymers that provide prolongation, selectivity, reduced side effects, preservation of therapeutic concentration in the body, reduced toxicity and increased specific effects of the drug. Were established limitations for carrier polymers in molecular construction and creation of polymer forms of drugs. A list of classes of drugs, for which the creation of their dosage forms is relevant, was also defined. Based on the results of the research, it was concluded that drug polymers and practical possibilities of their creation are in many cases unique and cannot be achieved with the use of low molecular weight drugs.



Shtilman M.I. Biomaterials are an important area of biomedical technologies // Herald of RSMU, 2016. No. 5.
[2] Vasiliev A.E. Medicinal polymers. The results of science and technology, 1981. volume-16. from. 3-119.
[3] Shtilman M.I. Polymers for medical and biological purposes. Moscow: Academic Book; 2006. 400 p.
[4] Milusheva R.Yu., Inoyatova F.H., Batyrbekov A.A., Rashidova S.Sh. "Hepatoprotective, anticoagulant and immuno-stimulating properties of chitosan BOMBYX MORI derivatives", Advances in chitin science, 2011, XI, 180-184
[5] Yunusov Kh.E., Rashidova S.Sh., Sarymsakov AA, Atakhanov A.A. Medico-biological polymers and prospects for their creation. Pharmaceutical Journal. Tashkent, 2011. - No. 3. - P. 27-35.
[6] Kasymova G.Z., Sabirova R.A., Milusheva R.Yu. The effect of different forms of chitosan on the redox processes in the liver in the metabolic syndrome "Physician-graduate" No. 3.3 (52), 2012 S.432-437 AcadSci book "Russia.
[7] Sidebotham R.L. "Adv. Carb. Chem., 1974, 30, 371-444.
[8] Rembaum A. "Applied Polymer Symp.", 1973, No. 22, 229-317.
[9] Ferutte P. "IeFarmaco, Ed. Sci. ", 1977, 32, No. 3, 220-236
[10] . Rashidova S.Sh., Milusheva R.Yu., Advances in Chitin Science, 10th International Conference of the European Chitin Society, Volume X1 St. Petersburg, 2011, pp. 230-235.
[11] Regelson W. In: "Water-Soluble Polymers". Ed. N. M. Bikales. N.Y. - L., "Plenum Press", 1973, p. 161-177.
[12] Butler G.B. "J. Polymer Sci., Polymer Symp. " 1975, No. 50, 160-180.
[13] Regelson W., Morahan P., Kaplan A. In: "Polyelectrolytes and their applications". Eds. A. Rembaum, E. Sefeny. 1975, 131-144.
[14] Breslov, D. S. "Pure Applied Chem.", 1976, 46, No. 2-4, 103-113.
[15] Ottenbrite R. M., Regelson W., Kaplan A., Carchman R., Morahan P., Munson A. In: "Polymeric Drugs". Eds. L. G. Donaruma, O. Vogl. N. Y. - San Francisco - L., Acad. Press, 1978, p. 263-303.
[16] Levy H. B., Ibid, p. 305-329.
[17] Regelson W. "J. Polymer Sci., Polymer Symp.", 1979, No. 66, 483-538.
[18] Sarymsakov A.A., Yunusov Kh.E., Atakhanov A.A., Rashidova S.Sh., "Medico-biological polymers and prospects of their creation" Pharmaceutical Journal, 2011.
[19] Yunusov Kh.E., Atakhanov A.A., Ashurov N.A., Sarymsakov A.A., Rashidova S.Sh. "Physicochemical studies of cotton cellulose and its derivatives containing silver nanoparticles" Chemistry of Natural Compounds: Volume 47, Issue 3 (2011), Page 415-418
[20] Vokhidova N.R., Sattarov M.E., Kareva N.D., and Rashidova S.Sh. Fungicide Features of the Nanosystems of Silkworm (Bombyxmori) Chitosan with Copper Ions // Microbiology, 2014, Vol. 83, No. 6, pp. 751-753. © Pleiades Publishing, Ltd., 2014.
[21] Regelson W., Holland J. F. "Nature", 1958, 181, No. 4601, 46-47.
[22] Kholturaev B.Dj., Atakhanov A.A., Sarymsakov A.A., «Obtaining polymer – containing blood-stopping drugs and their physico-chemical properties» “Development prospects of chemistry and technology of natural and synthetic polymers” Proceedings of the Republican Scientific and Technical conference, Tashkent 2019., 6061 p.
[23] Sarymsakov A.A., Rashidova S.Sh., Azizova M.A. “ Methods for producing a copolymer having properties against chronic respiratory viral infections based on gossypol and carboxomethyl cellulose” IAP 04811 Tashkent, 17.12.2013.
[24] Azizova M.A., Sarymsakov A.A., Rashidova S.Sh. “Synthesis and biomedical testing of polymeric forms of an interferon inducer with antiviral activity” “Development prospects of chemistry and technology of natural and synthetic polymers” Proceedings of the Republican Scientific and Technical conference, Tashkent 2019., 10-11 p.
[25] Kudyshkin V.O., Futoryanskaya AM, Milusheva R.Yu., Kareva N.D., Rashidova S.Sh. Synthesized graft copolymers of chitosan Bombyxmori and N- vinylcaprolactam. // DANRU, №2, 2010 С.60-63.
[26] Rashidova S.Sh., Milusheva R.Yu., Yugay S.M. "Nanomaterials Based on Chitosan of Bombyx mori", Advances in chitin science, 2011. XI. 230-235.
[27] Milusheva R.Yu., Song W., Rashidova S.Sh. // Bionanocomposites Based on Chitosan of Bombyx Mori and Sepiolite Pangel S9, Advances in chitin science, 2011, XI, 132-133.
[28] Sarymsakov AA, Li Yu.B., Rashidova S.Sh.. Eye medicinal films for the treatment of viral diseases of the eye. Korean Newsletter "Tinbo", 2014
[29] Ershov F.I., Sarymsakov A.A., Nesterenko V.G., Rashidova S.Sh. and etc. Patent of the Russian Federation No. 2270708, 2003; No. 2002755, 1993; No. 21478, 2000.
[30] Ringsdorf H. In: "Polymeric Drug Delivery Systems". Ed by Kostelnik B. N. Y., Gordon Breach, 1978, p. 197.
[31] Trouet A. In: Polymeric Drug Delivery Systems. Ed by Kostelnik B. N. Y., Gordon Breach, pp. 157-173.
[32] Sarymsakov A.A., Rashidova S.Sh., Aripova T.U. "New in the prevention and treatment of influenza and ARVI", Tashkent 2010, pp. -110
[33] Vokhidova N.R., Nurgaliyev I.N., Ashurov N.S., Yugay S.M., Rashidova S.Sh. Obtaining and stabilization mechanisms of cobalt nanoparticles based on chitosan bombyx mori 2015 CIS-Korea conference on science and technology, 2015. P. 270-273
[34] Yunusova Kh.E., Atakhanova A.A., Ashurova N.A., Sarymsakova A.A.,. Rashidova S.Sh. Physico-chemical studies of cotton cellulose derivatives containing silver nanoparticles. // Journal of "Chemistry of Natural Compounds" Uzbekistan 2011 № 3. P.370-373.
[35] Vokhidova N.R, Pirniyazov K.K, Rashidova S.Sh. Formation and stabilization of metal nanoparticles in polymer matrices. Review article. Proceedings of the Institute of Chemistry and Polymer Physics of the Academy of Sciences of Uzbekistan. Tashkent, 2011. - P.128-145.
[36] Yunusov Kh.E., Atakhanov AA, Sarymsakov AA, Rashidova S.Sh., Lobanova K.V., Tashpulatov Zh.Zh. Nanoparticles of silver, formed on polymer matrices and their bactericidal properties. Pharmaceutical Journal, №1, 2010, p. 55-59.
[37] Oksengendler BL, Turaeva N., Maksimov SE, Dzhurabekova FG, Peculiarities of the radiation defect formation in nanocrystals embedded in a solid matrix, ZhETF, v.138, issue 1 (7), 1- 6 (2010).
[38] Mailoa, M. N., Mahendradatta, M., Laga, A., & Djide, N. (2013). Tannin extract of guava leaves (Psidium guajava L) variation with concentration organic solvents. International Journal of Scientific & Technology Research, 2(9), 106-110.http://www.ijstr.org/final-print/sep2013/Tannin-Extract-Of-Guava-Leaves-Psidium-Guajava-L-Variation-With-Concentration-Organic-Solvents.pdf