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IJSTR >> Volume 5 - Issue 6, June 2016 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616

Biochemical Effects Of Aluminum On Some Selected Serum Enzymes Of Male Wistar Albino Rats

[Full Text]



Ogueche, P.N,Ogbu, A.E, Dike, C.C, Ugwu, C.E, Okonkwo, C.O.



Aluminum, Acid phosphatase and Alkali phostphatase, Serum, Toxicity.



Toxic metals are widely found in our environment and humans are exposed to them via water, contaminated air, food and soil. Aluminum (AL) belongs to this group of toxic metals. Its neurological effects are well documented but effects on acid and alkaline phosphatases are poorly studied and this the essence of this study. Toxicity of aluminum was investigated based on the elevation of acid and alkali phosphatases in serum of male Wistar albino rats after days 7 and 14 of aluminum (0.38, 3.8 and 38mg/kg body weight) administration respectively. The results showed significant increase (p<0.05) in serum acid phosphatase in the test animals given 38kg/kg after days 14 while serum alkali phosphatase increased significantly (p < 0.05) in the test animals given 3.8 and 38 mg/kg after days 7 and 14 when compared to the control animals. However, lower dose (0.38mg/kg) showed increase in both serum acid and alkali phosphatases respectively but were statistically non-significant (p>0.05) at 7 and 14, as compared to control animals.



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