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IJSTR >> Volume 6 - Issue 11, November 2017 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616

Influence of Cempaka Yellow Flower Extract (Michelia Champaca L.) on Lipid Profile on The Menopause Age Rate

[Full Text]



Meliani Sukmadewi Harahap, Fazdria, Nora Very, Lina



Cempaka Yellow Flower Exrtract, HDL, LDL, cholseterol total, menopause, age rate, winstar rats.



The number of women aged 50 years and over can be estimated to increase from 500 million at present to more than 1 billion in prediction during 2030. After entering menopause, the hormone estrogen in the body of women is decreased drastically. Decreased estrogen hormone makes LDL cholesterol difficult to control, high levels of LDL one of the factors causing coronary heart disease. Estrogen is a female hormone that has many functions, one of which is an antioxidant which controls of levels of cholesterol. The Cempaka Yellow Flower (Michelia champaca L) or known as the Flower Jeumpa in Aceh Province, one of the herbs which are useful as antioxidants, antimicrobials, anti-inflammatory, antidiabetic, and antifungal. The several components contain as: flavonoids, polyphenols, phenols, tannins, anthocyanins, glutathione and Vitamin C. The general objectives of this study were: To prove the effect of giving of Cempaka Yellow Flower extract (Michelia champaca L) has lipid profile in mouse age of menopause. The design of this study is true experimental design with the randomized posttest-only control group design approach. Measurements of HDL, LDL, triglyceride, and total cholesterol levels were performed only after the treatment of young flower extract was performed. The subjects of this study were female winstar rats age of menopause as many as 28 tail. The Cempaka Yellow Flower extract can lower LDL and cholesterol levels and can increase HDL levels. Yellow Cempaka able to decrease LDL and Cholesterol level and increase HDL level at optimum dose 300mg/KgWB/day .



[1] Ali, 2009. Do not Panic Facing the Abroad. http://lifestyle.okezone.com/read/2009/10/19/27/266918/Don’t-panic -passed-menopause (quoted on May 19, 2016)

[2] Anagnostis, P., Stevenson, J.C., Crook, D., Johnston, D.G., and Godsland, F, 2016. Effects of gender, age and menopausal status on serum apolipoprotein concentrations. Clinical Endocrinology Journal. DOI: 10.1111/cen.1308.

[3] Mozaffarian, 2016. Executive Summary: Heart Disease and Stroke Statistic-2016 Update, A Report From The American Heart Association. Circulation Journal 133, 447-454

[4] Hussain, M.A., Mamun, A., Peters, S., Woodward, M., and Huxley, R., 2016. The Burden of Cardiovascular Disease Attributable to Major Modifiable Risk Factors in Indonesia. Journal of Epidemiology. DOI: 10.2188 / jea.JE20150178.

[5] Mann, D.L., Zipes, D.P., Libby, P., Bnow, R.O., and Braunwald, E., 2016. Heart Disease. Elsevier Health Sciences.

[6] Rahal, A., Kumar, A., Singh, V., Chakraborty, S., and Dhama, K., 2010. Oxidative Stress, Prooxidants, and Antioxidants: The Interplay. Doi.org/10.1155/2014/761264.

[7] Nagavani, V., and Rao, R., 2010. Evaluation of Antioxidant Potential and Identification of Polyphenols by RP-HPLC in Michelia champaca Flowers, Advances in Biological Research 4, Vol.3, 159-168.

[8] Isidori, A, M., Giannetta, E., Greco, E, A., Gianfrilli, D., Bonifacio, V., Isidori, A., Lenzi, A., and Fabbri, A., 20015. Eggects of testosterone on body composition, bone metabolism and serum lipid profile in the middle-aged men: a meta-analysis. DOI: 10.1111/j.1365-2265.2005.02339.x

[9] Erem, C, 2006. Blood coagulation, fibrinolytic activity and lipid profile in subclinical thyroid disease: subclinical hyperthyroidism increases plasma factor X activity,Volume 64, ISSUE 3 March 2006, pages 323-329

[10] Mukuddem, J., Oosthuizen, W., and Jerling, J, C, 20015. A Systematic review of the Effects Of Nuts on Blood Lipid Profiles in Humnas, Vol 135, No. 9 2082-2089.

[11] Georgiadis, A, N., Papavasiliou, E, C., Lourida, E, S., Alamonas, Y., Kostara, C., Tselepis, A, D., and Drosos, A, A. 2006. Atherogenic lipids profile is a feature characteristic of patients with early rheumatoid arthritis: the effect of early treatment - a prospective, controlled study, DOI: 10.1186 / ar1952

[12] Sánchez-Rodríguez, M., Zacarías-Flore, Arronte-Rosales, Correa-Muñoz, E., Mendoza-Núñez., 2012 Menopause as risk factor for oxidative stress. The Journal of the North American Menopause Society, Vol. 19 , No.3, P 361-367.

[13] Burger, H., Woods, N., Dennerstein, L., Alexander, J.L., Kotz and Richardson, G., 2007. Nomenclature and endocrinology of menopause and perimenopause. Expert Review of Neurotherapeutics. Vol.7 No.1

[14] Jeon, s, M., Park, y, B., and Choi, M, s, 2004. Antihypercholesterolemic properties of naringin alters plasma and tissue lipids, cholesterol-regulating enzymes, fecal sterols and tissue morphology in rabbits. Volume 23, Issue 5, October 2004, Pages 1025-1034.

[15] Gaubatz, J, W., Heidemam, C., Gotto, A, M., Morrisett, J, D., and Dahlen, G, H, 2016. Human Plasma Lipoproteins Structural properties. J. Lipid Res. 57, 1339-1406.

[16] Cohen, J, C., Horton, J, D., and Hobbs, H, H., 2011. Human Fatty liver disease old questoions and new insights, Vol. 322, Issue 6037, pp. 1519-1523.

[17] Helmizar, Jalal and Liputo, I., 2010. Relationship Level of Consumption Antioxidant with Lipid Blood Profile of Minangkabau Ethnic Adult in Padang City. Indonesian Medical Magazine, Vol. 60 Number 8.J.S. Bridle, “Probabilistic Interpretation of Feedforward Classification Network Outputs, with Relationships to Statistical Pattern Recognition,” Neurocomputing—Algorithms, Architectures and Applications, F. Fogelman-Soulie and J. Herault, eds., NATO ASI Series F68, Berlin: Springer-Verlag, pp227-236, 1989. (Book style with paper title and editor).

[18] ectiveness of flavonoid extract and steroid from gedi (abelmoschus manihot) as anti obesity and hipolipidemik in white male rats wistar strain. Pharmacon Scientific Journals Pharmacy, Vol.2, No. 02.

[19] Ravishankar, D., Rajora, A, K., Greco, F., M, H., and Osbom, I. 2013. The International Journal Of Biochemistry & Cell Biology, Volume 42, Issue 12, 2821-2831.

[20] Hussein, M., Roby, H., Sarhan, M, A., Selim, K, A., And Khalel, I. 2013. Evaluation of antioxidant activity, total phenols and phenolic compounds in thyme (Thymus vulgaris L.) , sage (Salvia officinalis L.), and marjoram (Origanum majorana L.) extracts. Volume 43, Pages 827-831.

[21] Toth, P., Berylski, M., Nikoic, D., Rizzi, M., Montalto, G., and Banach, M, 2014. Best Practive & Research Clinical Endocrinology & Metabolism, Volume 28, Issue 3, 353-363.

[22] 30 Rastogi, S., Pandey, M, M., And Rawat, A, 2013. Phytomedicine, Volume 23, Issue 11, 1082-1089.

[23] Mata, R., Nakkala, J, R., and Sadras, S, R, 2015. Materials Science and Engineering, Vol. 51, 216-225.

[24] 32 Onakpoya., Spencer, E., H, C., and Thompson, 2014. Nutritions, Metabolism and Cardiovascular Diseases, Volume 24, Issue 7, 823-836.

[25] 33 Rahman, h., Reddy, V, B., Ghosh, S., Mistry, S, K., Pant, g., And Sibi, 2014. American Journal of life Science, DOI: 10.11648 / j.ajls.s.20140204.13 ISSN: 2328-5702 (Print); ISSN: 2328-5737 (Online)

[26] 34 Ogier, n., Amiot, M., Mallmann, C., Maraninchi, M., Morange, S., Lescuyer, J, F., and Cardinault, N, 2103. European Journal of Nutritions, Vol 52, Issue 2, 547-557

[27] 35 Bottger, S., and Melzig, M., 2013. The influence of saponins on cell membrane cholesterol. Bioorganic & Medicinal Chemistry Journal, Vol. 21, No. 22, 7118-7124

[28] 36. Hooper, L., Kroon, P., Rimm, E., Cohn, J., Harvey, I., Cornu, K., Ryder, J., Hall, W., and Cassidy, A., 2008. Flavonoids, flavonoids-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. The American Journal of Clinical Nutrition, Vol. 88 No.1, 38-50.