International Journal of Scientific & Technology Research

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IJSTR >> Volume 9 - Issue 3, March 2020 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616


[Full Text]



Elfira Sutanto, Elsha Dwi Anggun Rachmadhany, Ita Tazkiatul Izzati Mustopa, Elrian Syaputra, Monica Dwi Hartanti



Cervical cancer, DNA, HMGA2, HPV, Integration, KLF5, KLF12, SEMA3D.



Cervical cancer is the major cause of death of women in Indonesia after breast cancer. It is believed that the integration of Human Papilloma Virus plays a critical role in the development of cervical cancer. A recent study discovered "hot spots" contained candidate genes that are linked to the integration of DNA HPV to the host's genome. This preliminary study aims to investigate the expression of these genes in HPV-uninfected cervical cells. Most of the genes were expressed in HPV-uninfected cervical cells and their expression levels were significantly different from each other qualitatively and quantitatively, suggesting that these genes might have an important role in maintaining a normal function of cervical cells. Perturbation in the expression level of these genes might be linked to the developing of pathological conditions, such as cervical cancer.



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