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IJSTR >> Volume 6 - Issue 12, December 2017 Edition

International Journal of Scientific & Technology Research  
International Journal of Scientific & Technology Research

Website: http://www.ijstr.org

ISSN 2277-8616

A Randomized Open Label Comparative Clinical Study Of A Probiotic Against A Symbiotic In The Treatment Of Acute Diarrhea In Children

[Full Text]



Ramchandra Bastola, Bhawana Sigdel Bastola, Rupa Gurung , Jagat Jeevan Ghimire, Shree Krishna shrestha



Probiotic, Symbiotic, diarrhea, children



Objective: To evaluate the safety, efficacy and tolerability of a probiotic against a symbiotic in reducing the frequency and the duration of acute diarrhea. Methods: One hundred children aged 6 months to 6 years, with acute diarrhea, admitted in the Pediatric ward of Pokhara Academy of Health Sciences(PAHS) were recruited in the study. Group A (n = 50) received standard therapy plus probiotic 5 m (Enterogermina®) twice-daily for 7 days. Group B (n = 50) received standard treatment plus symbiotic 5 mL (Bifilac® dry syrup) twice-daily for 7 days. Patients were assessed for diarrhea and dehydration. Results: The frequency of diarrhea was reduced from 9.03 on Day 1 to 0.81 on Day 3 in Group B, compared with 10.1 on Day 1 to 6.24 on Day 3 in Group A. On comparing the two groups on Day 3, Group A produced a statistically significant reduction in the frequency of diarrhea. Similarly, there was a statistically significant reduction in the duration of diarrhea on comparing Group A with Group B. The mean duration of diarrhea was 36.2 hours in Group B, compared with 72.6 hours in Group A. The adverse events were mild and no serious adverse effects were reported. Conclusion: From our study, it can be concluded that the symbiotic is more effective in reducing the frequency and duration of diarrhea then the probiotic and is well-tolerated.



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